The maternal to zygotic transition in mammals.
The maternal to zygotic transition in mammals.
复制标题
哺乳动物的母体到合子的转变。
DOI：
10.1016/j.mam.2013.01.003
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发表时间：
2013-10
影响因子：
10.6
通讯作者：
Dean, Jurrien
中科院分区：
文献类型：
--
作者：
Li, Lei;Lu, Xukun;Dean, Jurrien
关键词：
在胚胎基因组激活之前，哺乳动物发育的起始事件是在母体控制下的，包括受精、多精受精的阻断和精子DNA的加工。配子结合后，转录惰性的精子DNA被重新包装到雄性原核中，雄性原核与雌性原核融合形成1细胞合子。胚胎转录开始于控制发育的母体到合子的转移。这种转变发生在一轮或几轮卵裂球卵裂后的物种特异性时间，对正常发育至关重要。然而，即使在胚胎基因组激活后，成功的发育也依赖于储存的母体成分，没有这些成分，胚胎就无法超越最初的细胞分裂。更好地了解母体到合子过渡的分子基础，包括受精，胚胎基因组的激活和卵裂阶段的发展将提供对早期人类发育的洞察，这将转化为再生医学和辅助生殖技术的临床应用。
Prior to activation of the embryonic genome, the initiating events of mammalian development are under maternal control and include fertilization, the block to polyspermy and processing sperm DNA. Following gamete union, the transcriptionally inert sperm DNA is repackaged into the male pronucleus which fuses with the female pronucleus to form a 1-cell zygote. Embryonic transcription begins during the maternal to zygotic transfer of control in directing development. This transition occurs at species-specific times after one or several rounds of blastomere cleavage and is essential for normal development. However, even after activation of the embryonic genome, successful development relies on stored maternal components without which embryos fail to progress beyond initial cell divisions. Better understanding of the molecular basis of maternal to zygotic transition including fertilization, the activation of the embryonic genome and cleavage-stage development will provide insight into early human development that should translate into clinical applications for regenerative medicine and assisted reproductive technologies.
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影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali
影响因子：
64.8
作者：
BRAUDE, P;BOLTON, V;MOORE, S
通讯作者：
MOORE, S
影响因子：
64.8
作者：
BARROS, C;YANAGIMACHI, R
通讯作者：
YANAGIMACHI, R
影响因子：
64.8
作者：
BARTOLOMEI, MS;ZEMEL, S;TILGHMAN, SM
通讯作者：
TILGHMAN, SM
DOI：
10.1530/jrf.0.0220129
发表时间：
1970-01-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
BRONSON, RA;MCLAREN, A
通讯作者：
MCLAREN, A