Androgens, growth factors, and risk of prostate cancer: the Multiethnic Cohort.
Androgens, growth factors, and risk of prostate cancer: the Multiethnic Cohort.
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DOI：
10.1002/pros.21125
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发表时间：
2010-06-01
期刊：
影响因子：
2.8
通讯作者：
Kolonel, Laurence N.
中科院分区：
文献类型：
--
作者：
Gill, Jasmeet K.;Wilkens, Lynne R.;Pollak, Michael N.;Stanczyk, Frank Z.;Kolonel, Laurence N.
雄激素和生长因子被认为与前列腺癌的风险有关，尽管过去的研究得出了不同的结果。我们在多种族队列中进行了一项前列腺癌风险生物标志物的巢式病例对照研究。我们比较了467例前列腺癌患者和934例正常对照者血清中睾酮、双氢睾酮（DHT）、性激素结合球蛋白（SHBG）、3α-雄甾烷葡糖苷酸（3α-diol G）、胰岛素样生长因子I（IGF-I）、IGF-II、胰岛素样生长因子结合蛋白1（IGFBP-1）和IGFBP-3的诊断前水平。对照组在地理位置（HI、LA）、种族、样本采集时的年龄（± 1岁）、样本采集日期（± 1个月）和时间（± 2小时）以及空腹状态（<6、6-7、8-9、10+小时）方面与病例匹配。采用多变量条件Logistic回归模型计算校正比值比（OR）和95%置信区间（CI）。血清睾酮、DHT、SHBG、3α-diol G、IGF-I、IGF-II、IGFBP-1和IGFBP-3浓度与前列腺癌风险无关。血清浓度四分位数趋势检验也未显示任何相关性。晚期前列腺癌患者及其匹配对照组的结果相对不变。然而，随访期相对较短（平均1.9年）。按种族组进行的分析显示，与第一个三分位数相比，第二个（OR=3.67，95% CI：1.63-8.24）和第三个（OR=2.96，95% CI：1.19-7.40）IGF-I血清水平三分位数中拉丁裔男性的风险增加。拉丁裔男性IGF-I风险增加值得进一步研究，具有更大的统计功效。
Androgens and growth factors are thought to be associated with prostate cancer risk, though past research has produced mixed results. We conducted a nested case-control study of biomarkers of prostate cancer risk within the Multiethnic Cohort. We compared prediagnostic levels of testosterone, dihydrotestosterone (DHT), sex hormone-binding globulin (SHBG), 3α-androstanediol glucuronide (3α-diol G), insulin-like growth factor I (IGF-I), IGF-II, insulin-like growth factor binding protein 1 (IGFBP-1), and IGFBP-3 in serum from 467 incident prostate cancer cases and 934 cancer-free controls. Controls were matched to the cases on geographic site (HI, LA), ethnicity, age at specimen collection (± 1 year), date (± 1 month) and time of day (± 2 hours) of sample collection, and fasting status (<6, 6-7, 8-9, 10+ hours). Multivariate conditional logistic regression models were used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Serum concentrations of testosterone, DHT, SHBG, 3α-diol G, IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were not associated with risk of prostate cancer. Tests for trend of quartiles of serum concentrations also did not show any association. Results were relatively unchanged for men with advanced prostate cancer and their matched controls. However, the follow-up period was relatively short (mean of 1.9 years). Analysis by ethnic group showed an increased risk for Latino men in the second (OR=3.67, 95% CI: 1.63-8.24) and third (OR=2.96, 95% CI:1.19-7.40) tertiles of IGF-I serum levels compared to the first tertile. The suggested increased risk for IGF-I in Latino men merits further study, with greater statistical power.
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影响因子：
2.1
作者：
Mohr, BA;Feldman, HA;McKinlay, JB
通讯作者：
McKinlay, JB
影响因子：
3.8
作者：
Severi, G;Morris, HA;Giles, GG
通讯作者：
Giles, GG
DOI：
10.1093/jnci/88.16.1118
发表时间：
1996-08-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Gann, PH;Hennekens, CH;Stampfer, MJ
通讯作者：
Stampfer, MJ
影响因子：
6.4
作者：
Weiss, Jocelyn M.;Huang, Wen-Yi;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
影响因子：
3.8
作者：
Severi, Gianluca;Morris, Howard A.;Giles, Graham G.
通讯作者：
Giles, Graham G.