SHARPIN is an endogenous inhibitor of β1-integrin activation.
SHARPIN is an endogenous inhibitor of β1-integrin activation.
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DOI：
10.1038/ncb2340
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发表时间：
2011-09-25
影响因子：
21.3
通讯作者：
中科院分区：
文献类型：
--
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Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and Kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. Here we identified SHARPIN as an important inactivator of β1-integrins in an RNAi-screen. SHARPIN inhibited β1-integrin functions in human cancer cells and primary leukocytes. Fibroblasts, leukocytes and keratinocytes from SHARPIN-deficient mice exhibited increased β1-integrin activity which was fully rescued by re-expression of SHARPIN. SHARPIN directly bound to a conserved cytoplasmic region of integrin α-subunits and inhibited recruitment of Talin and Kindlin to the integrin. Therefore, SHARPIN inhibits the critical switching of β1-integrins from inactive to active conformations.
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影响因子：
64.8
作者：
Ikeda, Fumiyo;Deribe, Yonathan Lissanu;Skanland, Sigrid S.;Stieglitz, Benjamin;Grabbe, Caroline;Franz-Wachtel, Mirita;van Wijk, Sjoerd J. L.;Goswami, Panchali;Nagy, Vanja;Terzic, Janos;Tokunaga, Fuminori;Androulidaki, Ariadne;Nakagawa, Tomoko;Pasparakis, Manolis;Iwai, Kazuhiro;Sundberg, John P.;Schaefer, Liliana;Rittinger, Katrin;Macek, Boris;Dikic, Ivan
通讯作者：
Dikic, Ivan
DOI：
10.1083/jcb.200907174
发表时间：
2010-03-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Askari JA;Tynan CJ;Webb SE;Martin-Fernandez ML;Ballestrem C;Humphries MJ
通讯作者：
Humphries MJ
影响因子：
4
作者：
Byron A;Humphries JD;Askari JA;Craig SE;Mould AP;Humphries MJ
通讯作者：
Humphries MJ
影响因子：
4.8
作者：
Gustin, JA;Maehama, T;Donner, DB
通讯作者：
Donner, DB
影响因子：
11.8
作者：
Caswell, Patrick T.;Spence, Heather J.;Norman, Jim C.
通讯作者：
Norman, Jim C.