Closed-loop insulin delivery: update on the state of the field and emerging technologies.
Closed-loop insulin delivery: update on the state of the field and emerging technologies.
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DOI：
10.1080/17434440.2022.2142556
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发表时间：
2022-11
影响因子：
3.1
通讯作者：
Hovorka, Roman
中科院分区：
文献类型：
--
作者：
Ware, Julia;Hovorka, Roman
关键词：
在过去的五年里，闭环胰岛素输送系统已经从研究转向实际应用。许多系统已经商业化，并越来越多地用于临床实践。鉴于该领域新发展的迅速性，了解当前系统的能力和关键相似性和差异性可能具有挑战性。本综述旨在提供闭环胰岛素给药系统领域的最新进展，包括新兴技术。我们总结了商业和新兴的纯胰岛素混合闭环系统治疗1型糖尿病的关键临床安全性和有效性证据。进行了文献检索，并确定了在自由生活条件下使用闭环系统的临床试验，以报告安全性和有效性数据。我们评论了闭环系统的新兴技术和新技术，以及闭环胰岛素输送的非技术优先事项。与标准治疗相比，商业混合闭环胰岛素输送系统是有效的，持续改善血糖控制。由于临床惰性和缺乏资源来接受医疗保健专业人员的技术发展，广泛采用仍然存在挑战。
Over the last five years, closed-loop insulin delivery systems have transitioned from research-only to real-life use. A number of systems have been commercialized and are increasingly used in clinical practice. Given the rapidity of new developments in the field, understanding the capabilities and key similarities and differences of current systems can be challenging. This review aims to provide an update on the state of the field of closed-loop insulin delivery systems, including emerging technologies. We summarize key clinical safety and efficacy evidence of commercial and emerging insulin-only hybrid closed-loop systems for type 1 diabetes. A literature search was conducted and clinical trials using closed-loop systems during free-living conditions were identified to report on safety and efficacy data. We comment on emerging technologies and adjuncts for closed-loop systems, as well as non-technological priorities in closed-loop insulin delivery. Commercial hybrid closed-loop insulin delivery systems are efficacious, consistently improving glycemic control when compared to standard therapy. Challenges remain in widespread adoption due to clinical inertia and the lack of resources to embrace technological developments by health care professionals.
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影响因子：
16.2
作者：
Atlas E;Nimri R;Miller S;Grunberg EA;Phillip M
通讯作者：
Phillip M
影响因子：
5
作者：
Barnard, Katharine D;Wysocki, Timothy;Hovorka, Roman
通讯作者：
Hovorka, Roman
影响因子：
19.6
作者：
Bally, Lia;Gubler, Philipp;Hovorka, Roman
通讯作者：
Hovorka, Roman
影响因子：
16.2
作者：
Amadou, Coralie;Franc, Sylvia;Penfornis, Alfred
通讯作者：
Penfornis, Alfred
影响因子：
8.2
作者：
Boughton CK;Hovorka R
通讯作者：
Hovorka R