Aqueous autotaxin and TGF-βs are promising diagnostic biomarkers for distinguishing open-angle glaucoma subtypes.
Aqueous autotaxin and TGF-βs are promising diagnostic biomarkers for distinguishing open-angle glaucoma subtypes.
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房水自分泌运动因子和TGF-βs是区分开角型青光眼亚型的有前景的诊断生物标志物。
DOI：
10.1038/s41598-021-81048-3
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发表时间：
2021-01-14
影响因子：
4.6
通讯作者：
Aihara M
中科院分区：
文献类型：
--
作者：
Igarashi N;Honjo M;Asaoka R;Kurano M;Yatomi Y;Igarashi K;Miyata K;Kaburaki T;Aihara M
本研究的目的是检查水相自分泌运动因子（ATX）和TGF-β水平是否可用于区分青光眼亚型。这项前瞻性观察性研究使用从281名连续患者中获得的房水样本进行。将开角型青光眼患者分为三组：原发性开角型青光眼（POAG）、继发性开角型青光眼（SOAG）和剥脱性青光眼（XFG）。定量ATX和TGF-βs的房水水平。在应用三种机器学习方法后，使用四个指标-ATX、TGF-β1、TGF-β2和TGF-β3分类为正常和青光眼亚型的AUC以及灵敏度和特异性。ATX、TGF-β1、TGF-β3与眼压呈正相关，ATX与平均差呈显著负相关。根据最小绝对收缩和选择算子回归分析，当使用四个变量时，区分每个亚组[正常、POAG、SOAG和XFG]的AUC值范围在0.675（POAG与正常）和0.966（XFG与正常）之间。ATX用于区分XFG与正常眼，TGF-β3用于区分XFG与正常眼、POAG或SOAG，获得了高AUC值。房水TGF-β和ATX在检测青光眼亚型中具有较高的诊断性能，并且可能是青光眼的有希望的生物标志物。
The purpose of this study is to examine if aqueous autotaxin (ATX) and TGF-β levels could be used for differentiating glaucoma subtypes. This prospective observational study was performed using aqueous humor samples obtained from 281 consecutive patients. Open angle glaucoma patients were classified into three groups: primary open-angle glaucoma (POAG), secondary open-angle glaucoma (SOAG), and exfoliation glaucoma (XFG). Aqueous levels of ATX and TGF-βs were quantified. The AUC as well as sensitivity and specificity for the classification into normal and glaucoma subtypes using four indicators-ATX, TGF-β1, TGF-β2, and TGF-β3, upon the application of three machine learning methods. ATX, TGF-β1, and TGF-β3 were positively correlated with IOP, and ATX was significantly and negatively correlated with the mean deviation. From least absolute shrinkage and selection operator regression analysis, the AUC values to distinguish each subgroup [normal, POAG, SOAG, and XFG] ranged between 0.675 (POAG vs. normal) and 0.966 (XFG vs. normal), when four variables were used. High AUC values were obtained with ATX for discriminating XFG from normal eyes and with TGF-β3 for discriminating XFG from normal eyes, POAG, or SOAG. Aqueous TGF-β and ATX exhibited high diagnostic performance in detecting glaucoma subtypes, and could be promising biomarkers for glaucoma.
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