Glutathione and modulation of cell apoptosis.
Glutathione and modulation of cell apoptosis.
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DOI：
10.1016/j.bbamcr.2012.06.019
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发表时间：
2012-10
影响因子：
5.1
通讯作者：
Aw, Tak Yee
中科院分区：
文献类型：
--
作者：
Circu, Magdalena L.;Aw, Tak Yee
关键词：
细胞凋亡是一种高度组织化的细胞死亡形式，对组织稳态、器官发育和衰老非常重要。迄今为止，外源性（死亡受体介导的）和内源性（线粒体衍生的）凋亡途径已在哺乳动物细胞中得到表征。还原型谷胱甘肽（GSH）是最常见的细胞巯基，在维持还原的细胞内环境中起着重要作用。GSH保护细胞大分子如DNA、蛋白质和脂质免受氧化、环境和细胞毒性剂的侵害，强调了其中心抗凋亡功能。活性氧和氮物质（ROS/RNS）可氧化细胞GSH或诱导其胞外输出，导致细胞内氧化还原稳态的丧失和凋亡信号级联的激活。最近的证据揭示了GSH参与细胞凋亡信号通路的新作用，其中蛋白质氧化还原活性半胱氨酸的翻译后S-谷胱甘肽化与细胞凋亡的增强有关。在本综述中，我们重点关注与凋亡信号相关的GSH氧化还原机制的关键方面，包括：（a）通过GSH氧化或GSH转运与凋亡级联反应的启动或传播相关的细胞GSH氧化还原稳态的变化，以及（B）S-谷胱甘肽在蛋白质调节和凋亡启动中的证据。
Apoptosis is a highly organized form of cell death that is important for tissue homeostasis, organ development and senescence. To date, the extrinsic (death receptor mediated) and intrinsic (mitochondria derived) apoptotic pathways have been characterized in mammalian cells. Reduced glutathione, GSH, is the most prevalent cellular thiol that plays an essential role in preserving a reduced intracellular environment. GSH protection of cellular macromolecules like DNA, proteins and lipids against oxidizing, environmental and cytotoxic agents, underscores its central anti-apoptotic function. Reactive oxygen and nitrogen species (ROS/RNS) can oxidize cellular GSH or induce its extracellular export leading to the loss of intracellular redox homeostasis and activation of the apoptotic signaling cascade. Recent evidence uncovered a novel role for GSH involvement in apoptotic signaling pathways wherein post-translational S-glutathiolation of protein redox active cysteines is implicated in the potentiation of apoptosis. In the present review we focus on the key aspects of GSH redox mechanisms associated with apoptotic signaling that includes: (a) changes in cellular GSH redox homeostasis through GSH oxidation or GSH transport in relation to the initiation or propagation of the apoptotic cascade, and (b) evidence for S-glutathiolation in protein modulation and apoptotic initiation.
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影响因子：
7.4
作者：
Circu, Magdalena L.;Aw, Tak Yee
通讯作者：
Aw, Tak Yee
影响因子：
7.4
作者：
Circu, Magdalena L.;Rodriguez, Cynthia;Aw, Tak Yee
通讯作者：
Aw, Tak Yee
影响因子：
29.4
作者：
Colell, A;Gargía-Ruiz, C;Fernández-Checa, JC
通讯作者：
Fernández-Checa, JC
影响因子：
4.8
作者：
Aon, Miguel A.;Cortassa, Sonia;O'Rourke, Brian
通讯作者：
O'Rourke, Brian
影响因子：
25.7
作者：
Cazanave, Sophie;Berson, Alain;Pessayre, Dominique
通讯作者：
Pessayre, Dominique