Anti-neutral endopeptidase, natriuretic peptides disarrangement, and proteinuria onset in membranous nephropathy
Anti-neutral endopeptidase, natriuretic peptides disarrangement, and proteinuria onset in membranous nephropathy
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膜性肾病中的抗中性内肽酶、利尿钠肽紊乱和蛋白尿发作
DOI：
10.1007/s11033-012-2367-4
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发表时间：
2013-04
影响因子：
2.8
通讯作者：
Qin, Yuan Han
中科院分区：
文献类型：
--
作者：
Hu, Peng;Xuan, Qiang;Hu, Bo;Lu, Ling;Qin, Yuan Han
Neutral endopeptidase (NEP) is the first podocytic antigen responsible for human membranous nephropathy (MN). Besides the prevailing pathogenetic mechanism of immune complex, NEP is also involved in the metabolism of natriuretic peptides (NP). The identification of anti-NEP antibodies in human MN suggests that the decreased circulating NEP may down-regulate the NP catabolism. In this context, we hypothesize that NP disarrangement secondary to anti-NEP antibodies may account, in part, for the onset of proteinuria in MN. Whereas the pathways for the onset of proteinuria caused by elevated NP level are still obscure. The data presented in this review focus on those which support this hypothesis with regards to evidence from the glomerular haemodynamic changes, endothelial permeability, glomerular basement membrane disruption, and podocyte detachment.
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DOI：
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DOI：
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发表时间：
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期刊：
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影响因子：
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DOI：
10.1677/joe.0.1580035
发表时间：
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影响因子：
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