Protective effects of lactic acid bacteria-fermented soymilk against chronic cadmium toxicity in mice
Protective effects of lactic acid bacteria-fermented soymilk against chronic cadmium toxicity in mice
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乳酸菌发酵豆奶对小鼠慢性镉中毒的保护作用
DOI：
10.1039/c4ra12865f
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发表时间：
2015
期刊：
影响因子：
3.9
通讯作者：
Chen Wei
中科院分区：
文献类型：
--
作者：
Zhai Qixiao;Xiao Yue;Tian Fengwei;Wang Gang;Zhao Jianxin;Liu Xiaoming;Chen Yong Q.;Zhang Hao;Chen Wei
我们前期的研究证实植物乳杆菌CCFM8610对小鼠慢性镉中毒具有保护作用，而L.保加利亚CCFM8004不能提供类似的保护。本研究旨在评价这些乳酸菌发酵的豆奶对小鼠慢性镉中毒的保护作用，并深入了解豆奶和这些菌株的联合作用机制。实验小鼠分为对照组、单纯镉组、未发酵豆奶镉组、CCFM8610发酵豆奶镉组和CCFM8004发酵豆奶镉组。各组均治疗8周。在粪便和组织中测量镉的水平，并注意到镉毒性的几个生物标志物的改变。结果表明，非发酵豆浆对小鼠慢性镉中毒的保护作用有限。然而，口服L.植物乳杆菌CCFM8610发酵豆奶能够增加小鼠粪便中Cd的排泄，降低组织中Cd的负荷，减轻组织中的氧化应激，逆转肝、肾损伤生物标志物的变化，改善组织的组织病理学变化。植物CCFM8610发酵豆奶可作为镉慢性中毒的膳食治疗策略。对L.保加利亚CCFM8004发酵豆奶提供了类似的保护，尽管效果不如CCFM8610处理显著。菌株与豆乳的协同作用可能是由于发酵后提高了豆乳的排镉能力和抗氧化能力。
Our previous study confirmed that Lactobacillus plantarum CCFM8610 has protective effects against chronic cadmium (Cd) toxicity in mice, whereas L. bulgaricus CCFM8004 fails to provide similar protection. This study was designed to evaluate the protective effects of soymilk fermented with these lactic acid bacteria, against chronic Cd toxicity in mice, and to give an insight into the mechanism of the conjunct effect of soymilk and these strains. Experimental mice were divided into five groups as control, Cd only, non-fermented soymilk plus Cd, CCFM8610-fermented soymilk plus Cd, and CCFM8004-fermented soymilk plus Cd. The treatment of all groups was carried out for 8 weeks. Levels of Cd were measured in feces and tissues, and alterations in several biomarkers of Cd toxicity were noted. The results showed that non-fermented soymilk gave limited protection against chronic Cd toxicity in mice. However, oral administration of L. plantarum CCFM8610-fermented soymilk was able to increase fecal Cd excretion, reduce tissue Cd burden, alleviate tissue oxidative stress, reverse changes in hepatic and renal damage biomarkers, and ameliorate tissue histopathological changes in mice, indicating that L. plantarum CCFM8610-fermented soymilk could be considered as a dietary therapeutic strategy against chronic Cd toxicity. The treatment of L. bulgaricus CCFM8004-fermented soymilk provided similar protection, although the effects were less significant than for CCFM8610 treatment. The conjunct effects of the strains and the soymilk may be attributed to the increased Cd excretion ability and antioxidative capacity after fermentation.
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影响因子：
3.8
作者：
M. F. Pérez Díaz;M. Acosta;F. Mohamed;M. Ferramola;L. Oliveros;M. Giménez
通讯作者：
M. F. Pérez Díaz;M. Acosta;F. Mohamed;M. Ferramola;L. Oliveros;M. Giménez
影响因子：
5.8
作者：
Matti J. Tikkanen;Herman Adlercreutz
通讯作者：
Matti J. Tikkanen;Herman Adlercreutz
影响因子：
5.6
作者：
Marazza, Jose A.;LeBlanc, Jean Guy;Garro, Marisa S.
通讯作者：
Garro, Marisa S.
DOI：
10.1080/00984109708984058
发表时间：
1997-10
期刊：
Journal of toxicology and environmental health
影响因子：
--
作者：
Heping Yan;C. Carter;Cunyong Xu;Pramod K. Singh;Mark M. Jones;Joyce E. Johnson;Mary S. Dietrich
通讯作者：
Heping Yan;C. Carter;Cunyong Xu;Pramod K. Singh;Mark M. Jones;Joyce E. Johnson;Mary S. Dietrich
影响因子：
5.4
作者：
Q. Wei;Tong-Rong Chen;Jyun-Ting Chen
通讯作者：
Q. Wei;Tong-Rong Chen;Jyun-Ting Chen