Morphogenetically Specific Mutability in DROSOPHILA ANANASSAE.
Morphogenetically Specific Mutability in DROSOPHILA ANANASSAE.
复制标题
果蝇形态发生特异性突变。
作者：
C. W. Hinton
对影响光学形态的可见突变体（Om）表现出超可变性的股票进行了遗传分析。 Om 突变体的产生，以每 10(4) 两个的频率独立恢复，仅限于女性，并且主要取决于其 X 染色体的纯合性；在杂合子中，Om 突变性是由之前在其他具有神秘突变系统的种群中发现的两种染色体外复制元件之一的存在所刺激的。半显性和非多效性 Om 突变体与总重排无关，它们映射到至少 15 个基因座。通过作图定义的大多数基因座由两个或多个 Om 突变体代表，尽管有相当多的基因座间拟态，但有时会表现出基因座特异性表型。 Om 突变体具有中等程度的不稳定，并且它们受到在两个 X 连锁基因座中的任一个自发产生的显性抑制子的影响。对这些观察结果的解释引用了一个 X 连锁转座元件 (tom)，该元件专门插入到一组参与眼睛形态发生的结构基因共享的控制序列中。
A stock exhibiting hypermutability with respect to visible mutants (Om) affecting optic morphology was subjected to genetic analysis. The production of Om mutants, independently recovered with a frequency of two per 10(4), is restricted to females and depends primarily on homozygosity of their X chromosomes; in heterozygotes, Om mutability is stimulated by the presence of either one of two extrachromosomally replicating elements previously identified in other stocks having cryptic mutability systems. The semidominant and nonpleiotropic Om mutants are not associated with gross rearrangements and they map to at least 15 loci. Most of the loci defined by mapping are represented by two or more Om mutants which, despite considerable interlocus mimicry, sometimes display locus-specific phenotypes. Om mutants are moderately unstable, and they are subject to dominant suppressors that arise spontaneously at either of two X-linked loci. An interpretation of these observations invokes an X-linked transposable element (tom) that specifically inserts into control sequences shared by a set of structural genes involved in eye morphogenesis.
果蝇突变抑制系统中的核细胞质关系。
影响因子：
3.3
作者：
Hinton,CW
通讯作者：
Hinton,CW