Appearance of B220low autoantibody‐producing B‐1 cells at neonatal and older stages in mice
Appearance of B220low autoantibody‐producing B‐1 cells at neonatal and older stages in mice
复制标题
小鼠新生期和老年期产生 B220low 自身抗体的 B-1 细胞的出现
DOI：
10.1111/j.1365-2249.2008.03709.x
复制
发表时间：
2008
影响因子：
4.6
通讯作者：
Toru Abo
中科院分区：
文献类型：
--
作者：
S. Tachikawa;T. Kawamura;H. Kawamura;Yasuhiro Kanda;Y. Fujii;Hiroaki Matsumoto;Toru Abo
在这项研究中，正常成年小鼠在脾和肝中携带高B220常规B细胞，但在骨髓中同时携带高B220和低B220。而在新生期，这些器官中只有B220低的非常规B细胞。这种模式持续到出生后2周，在这个阶段在血清中检测到自身抗体。这一现象在所有受试的幼鼠(1-2周)中都可以看到，无论性别如何。此外，在较老的阶段(20周以上)，B220低细胞在脾和肝中重新出现，这些B220低细胞在骨髓中成为主导。这些老年小鼠的血清中也重新出现了自身抗体。细胞分选实验表明，B220low细胞能够在体外对内毒素刺激产生自身抗体。这些结果表明，B220低细胞同时出现在新生儿和老年阶段，作为生理反应，并最终产生自身抗体。
In this study, normal adult mice carried B220high conventional B cells in the spleen and liver, but carried both B220high and B220low in the bone marrow. However, at the neonatal stage, only B220low unconventional B cells were found in all these organs. This pattern continued up to 2 weeks after birth, and at this stage autoantibodies were detected in the sera. This phenomenon was seen in all tested young mice (1–2 weeks), irrespective of their gender. Furthermore, at older stages (more than 20 weeks), B220low cells reappeared in the spleen and liver, and these B220low cells became dominant in the bone marrow. Autoantibodies also reappeared in the sera of these older mice. Cell‐sorting experiments revealed that B220low cells were able to produce autoantibodies upon lipopolysaccharide stimuli in vitro. These results suggest that B220low cells appear at both neonatal and older stages as physiological responses and eventually produce autoantibodies.
lpr 和 gld 小鼠脾脏和骨髓 B 细胞的表型异常。
DOI：
10.1006/clin.1996.0004
发表时间：
1996
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Reap,EA;Piecyk,ML;Oliver,A;Sobel,ES;Waldschmidt,T;Cohen,PL;Eisenberg,RA
通讯作者：
Eisenberg,RA
胸腺功能、衰老和自身免疫。
影响因子：
4.4
作者：
Rose,NR
通讯作者：
Rose,NR
DOI：
10.1073/pnas.89.8.3320
发表时间：
1992-04-15
影响因子：
11.1
作者：
KANTOR, AB;STALL, AM;HERZENBERG, LA
通讯作者：
HERZENBERG, LA