Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?
复制标题
补偿性突变是否促进了当前耐多药结核病的流行？
DOI：
10.1038/s41426-018-0101-6
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发表时间：
2018-06-06
影响因子：
13.2
通讯作者：
Gao Q
中科院分区：
文献类型：
--
作者：
Liu Q;Zuo T;Xu P;Jiang Q;Wu J;Gan M;Yang C;Prakash R;Zhu G;Takiff HE;Gao Q
Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-based collection of MDR-TB strains from Shanghai (the most populous city in China) and 1346 published global MDR-TB strains. We report that MDR-TB strains with compensatory mutations in therpoA,rpoB, orrpoCgenes were neither more frequently clustered nor found in larger clusters than those without compensatory mutations. Our results suggest that compensatory mutations are not a major contributor to the current epidemic of MDR-TB.
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