Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage.
Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage.
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DOI：
10.1016/j.taap.2010.08.013
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发表时间：
2010-11-15
影响因子：
3.8
通讯作者：
Giri AK
中科院分区：
文献类型：
--
作者：
Banerjee M;Banerjee N;Ghosh P;Das JK;Basu S;Sarkar AK;States JC;Giri AK
通过受污染的饮用水慢性砷暴露是一个主要的环境健康问题。慢性砷暴露通过多种机制发挥其毒性作用，其中活性氧（ROS）的产生是最重要的机制之一。高水平的ROS反过来会导致DNA损伤，最终可能导致癌症。为了保持ROS水平的平衡，存在一系列酶，其中过氧化氢酶（CAT）和髓过氧化物酶（MPO）是重要的成员。因此，在这项研究中，我们测定了这两种酶的活性在血清中和外周血淋巴细胞染色体畸变（CA）在饮用水砷暴露和非暴露的个人。饮用水和尿液中的砷被用作暴露的量度。我们的研究结果表明，个人长期接触砷有显着较高的CAT和MPO活性和CA的发病率较高。我们发现中度正相关的CAT和MPO活性，诱导CA和砷的尿和水。这些结果表明，慢性砷暴露导致较高的CAT和MPO活性与诱导的遗传损伤的血清中。我们的结论是，这些酶的血清水平可能被用作早期砷暴露诱导的疾病的生物标志物之前，砷中毒的经典皮肤病症状开始出现。
Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. High level of ROS, in turn, leads to DNA damage that might ultimately culminate in cancer. In order to keep the level of ROS in balance, an array of enzymes is present, of which catalase (CAT) and myeloperoxidase (MPO) are important members. Hence, in this study, we determined the activites of these two enzymes in the sera and chromosomal aberrations (CA) in peripheral blood lymphocytes in individuals exposed and unexposed to arsenic in drinking water. Arsenic in drinking water and in urine was used as a measure of exposure. Our results show that individuals chronically exposed to arsenic have significantly higher CAT and MPO activity and higher incidence of CA. We found moderate positive correlations between CAT and MPO activities, induction of CA and arsenic in urine and water. These results indicate that chronic arsenic exposure causes higher CAT and MPO activity in serum that correlates with induction of genetic damage. We conclude that the serum levels of these enzymes might be used as biomarkers of early arsenic exposure induced disease much before the classical dermatological symptoms of arsenicosis begin to appear.
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影响因子：
3.8
作者：
Biswas, Debabrata;Banerjee, Mayukh;Biswas, Tuli
通讯作者：
Biswas, Tuli
影响因子：
4.5
作者：
Banerjee, Nilanjana;Banerjee, Mayukh;Giri, Ashok K.
通讯作者：
Giri, Ashok K.
影响因子：
4.1
作者：
Lin, S;Cullen, WR;Thomas, DJ
通讯作者：
Thomas, DJ
影响因子：
3.8
作者：
Kligerman, A. D.;Tennant, A. H.
通讯作者：
Tennant, A. H.
影响因子：
3.8
作者：
Hossain, MK;Khan, MMH;Mori, M
通讯作者：
Mori, M