Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.
Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.
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DOI：
10.1016/j.biopsych.2012.12.019
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发表时间：
2013-04-15
影响因子：
10.6
通讯作者：
Shaham, Yavin
中科院分区：
文献类型：
--
作者：
Theberge, Florence R.;Li, Xuan;Kambhampati, Santa;Pickens, Charles L.;Laurent, Robyn St.;Bossert, Jennifer M.;Baumann, Michael H.;Hutchinson, Mark R.;Rice, Kenner C.;Watkins, Linda R.;Shaham, Yavin
Recent evidence implicates toll-like receptor 4 (TLR4) in opioid analgesia, tolerance, conditioned place preference, and self-administration. Here we determined the effect of the TLR4 antagonist (+)-naltrexone (a μ-opioid receptor inactive isomer) on the time-dependent increases in cue-induced heroin seeking after withdrawal (incubation of heroin craving). In an initial experiment, we trained rats for 9 h/day to self-administer heroin (0.1 mg/kg/infusion) for 9 days; lever presses were paired with a 5-sec tone-light cue. We then assessed cue-induced heroin seeking in 30-min extinction sessions on withdrawal day 1; immediately after testing, we surgically implanted rats with Alzet minipumps delivering (+)-naltrexone (0, 7.5, 15, 30 mg/kg/day, s.c.) for 14 days. We then tested the rats for incubated cue-induced heroin seeking in 3-h extinction tests on withdrawal day 13. We found that chronic delivery of (+)-naltrexone via minipumps during the withdrawal phase decreased incubated cue-induced heroin seeking. In follow-up experiments, we found that acute injections of (+)-naltrexone immediately before withdrawal day 13 extinction test had no effect on incubated cue-induced heroin seeking. Furthermore, chronic delivery of (+)-naltrexone (15 or 30 mg/kg/day) or acute systemic injections (15 or 30 mg/kg) had no effect on ongoing extended access heroin self-administration. Finally, in rats trained to self-administer methamphetamine (0.1 mg/kg/infusion, 9 h/d, 9 days), chronic delivery of (+)-naltrexone (30 mg/kg/day) during the withdrawal phase had no effect on incubated cue-induced methamphetamine seeking. The present results suggest a critical role of TLR4 in the development of incubation of heroin, but not methamphetamine, craving.
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影响因子：
3.4
作者：
Bossert, Jennifer M.;Wihbey, Kristina A.;Pickens, Charles L.;Nair, Sunila G.;Shaham, Yavin
通讯作者：
Shaham, Yavin
影响因子：
3.6
作者：
Greenwell, Thomas N.;Walker, Brendan M.;Cottone, Pietro;Zorrilla, Eric P.;Koob, George F.
通讯作者：
Koob, George F.
影响因子：
3.6
作者：
Bienkowski, P;Koros, E;Bogucka-Bonikowska, A
通讯作者：
Bogucka-Bonikowska, A
影响因子：
2.3
作者：
Ben-Shahar, Osnat;Obara, Ilona;Ary, Alexis W.;Ma, Natalie;Mangiardi, Mario A.;Medina, Robert L.;Szumlinski, Karen K.
通讯作者：
Szumlinski, Karen K.
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC