Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect
Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect
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Akermanite 用作碱性可生物降解植入物，用于治疗骨质疏松性骨缺损
DOI：
10.1016/j.bioactmat.2016.11.004
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发表时间：
2016-12
影响因子：
18.9
通讯作者：
Pan Haobo
中科院分区：
文献类型：
--
作者：
Liu Wenlong;Wang Ting;Zhao Xiaoli;Dan Xiuli;Lu William W.;Pan Haobo
In osteoporosis scenario, tissue response to implants is greatly impaired by the deteriorated bone regeneration microenvironment. In the present study, a Mg-containing akermanite (Ak) ceramic was employed for the treatment of osteoporotic bone defect, based on the hypothesis that both beneficial ions (e.g. Mg2+ ect.) released by the implants and the weak alkaline microenvironment pH (me-pH) it created may play distinct roles in recovering the abnormal bone regeneration by stimulating osteoblastic anabolic effects. The performance of Ak, beta-tricalcium phosphate (beta-TCP) and Hardystone (Har) in healing a 3 mm bone defect on the ovariectomized (OVX) osteoporotic rat model was evaluated. Our results indicated that, there's more new bone formed in Ak group than in beta-TCP or Har group at week 9. The initial me-pHs of Ak were significantly higher than that of the beta-TCP and Blank group, and this weak alkaline condition was maintained till at least 9 weeks post-surgery. Increased osteoblastic activity which was indicated by higher osteoid secretion was observed in Ak group at week 4 to week 9. An intermediate layer which was rich in phosphorus minerals and bound directly to the new forming bone was developed on the surface of Ak. In a summary, our study demonstrates that Ak exhibits a superior bone regenerative performance under osteoporosis condition, and might be a promising candidate for the treatment of osteoporotic bone defect and fracture. (C) 2016 The Authors. Production and hosting by Elsevier B.V .on behalf of KeAi Communications Co., Ltd.
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DOI：
10.1520/stp48112s
发表时间：
1937
期刊：
--
影响因子：
--
作者：
J. L. Haughlinton;W. E. Prytherch
通讯作者：
J. L. Haughlinton;W. E. Prytherch
DOI：
10.1142/9781786341341_0008
发表时间：
2017-02
期刊：
--
影响因子：
--
作者：
T. Yokoi;T. Miyazaki;M. Kawashita;C. Ohtsuki
通讯作者：
T. Yokoi;T. Miyazaki;M. Kawashita;C. Ohtsuki
锶取代硅酸钙生物活性陶瓷增强骨质疏松骨再生
影响因子：
14
作者：
Lin, Kaili;Xia, Lunguo;Chang, Jiang
通讯作者：
Chang, Jiang
影响因子：
3.5
作者：
N. Saito;N. Tabata;Saburou Saito;Yoshihisa Andou;Yukiko Onaga;Akihiro Iwamitsu;M. Sakamoto;Tuyoshi Hori;H. Sayama;T. Kawakita
通讯作者：
N. Saito;N. Tabata;Saburou Saito;Yoshihisa Andou;Yukiko Onaga;Akihiro Iwamitsu;M. Sakamoto;Tuyoshi Hori;H. Sayama;T. Kawakita
影响因子：
2.9
作者：
Wu, Chengtie;Chang, Jiang
通讯作者：
Chang, Jiang