Epigenetic Clock Deceleration and Maternal Reproductive Efforts: Associations With Increasing Gray Matter Volume of the Precuneus.
Epigenetic Clock Deceleration and Maternal Reproductive Efforts: Associations With Increasing Gray Matter Volume of the Precuneus.
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DOI：
10.3389/fgene.2022.803584
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发表时间：
2022
影响因子：
3.7
通讯作者：
Tomoda A
中科院分区：
文献类型：
--
作者：
Nishitani S;Kasaba R;Hiraoka D;Shimada K;Fujisawa TX;Okazawa H;Tomoda A
生育方面的努力，如怀孕、分娩和与孩子的互动，使母亲的大脑更适合养育孩子。然而，对非人类物种的广泛研究揭示了繁殖努力和预期寿命之间的权衡。在人类中，大规模的人口统计学研究表明，大多数情况下都是如此；然而，关于衰老的分子标记研究仍然存在争议。目前还没有研究同时评估生殖努力、衰老和大脑结构之间的关系。因此，我们研究了51位年龄在27-46岁的幼儿母亲的生殖努力（胎次状态、分娩次数、母性期和累积母性期）、DNA甲基化年龄（mAge）加速（基于Horvath的多组织时钟和皮肤与血液时钟）和区域灰质体积（通过使用基于体素的形态测定法的脑磁共振成像（MRI）获得）之间的关系。我们发现，即使在多元线性回归模型中调整了混杂效应之后，生育努力的增加与有一到四个孩子的母亲的衰老减速显著相关。左侧楔前叶灰质体积随着衰老速度的减慢而增大；另一方面，左侧楔前叶灰质体积增加介导了奇偶状态与mAge减速之间的关系。我们的研究结果表明，儿童早期的母亲，如果有少于四个孩子，可能会受益于楔前叶结构变化介导的衰老减速。
Reproductive efforts, such as pregnancy, delivery, and interaction with children, make maternal brains optimized for child-rearing. However, extensive studies in non-human species revealed a tradeoff between reproductive effort and life expectancy. In humans, large demographic studies have shown that this is the case for the most part; however, molecular marker studies regarding aging remain controversial. There are no studies simultaneously evaluating the relationship between reproductive effort, aging, and brain structures. We therefore examined the associations between reproductive efforts (parity status, number of deliveries, motherhood period, and cumulative motherhood period), DNA methylation age (mAge) acceleration (based on Horvath’s multi-tissue clock and the skin & blood clock), and the regional gray matter volumes (obtained through brain magnetic resonance imaging (MRI) using voxel-based morphometry) in 51 mothers aged 27–46 years of children in early childhood. We found that increasing reproductive efforts were significantly associated with decelerated aging in mothers with one to four children, even after adjusting for the confounding effects in the multiple linear regression models. We also found that the left precuneus gray matter volume was larger as deceleration of aging occurred; increasing left precuneus gray matter volume, on the other hand, mediates the relationship between parity status and mAge deceleration. Our findings suggest that mothers of children in early childhood, who have had less than four children, may benefit from deceleration of aging mediated via structural changes in the precuneus.
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影响因子：
6.1
作者：
Kresovich, Acob K.;Harmon, Quaker E.;Taylor, Jack A.
通讯作者：
Taylor, Jack A.
影响因子：
7.6
作者：
Katrinli, Seyma;Stevens, Jennifer;Smith, Alicia K.
通讯作者：
Smith, Alicia K.
影响因子：
4.6
作者：
Bolund E;Lummaa V;Smith KR;Hanson HA;Maklakov AA
通讯作者：
Maklakov AA
DOI：
10.18632/aging.101414
发表时间：
2018-04-18
期刊：
Aging
影响因子：
--
作者：
Levine ME;Lu AT;Quach A;Chen BH;Assimes TL;Bandinelli S;Hou L;Baccarelli AA;Stewart JD;Li Y;Whitsel EA;Wilson JG;Reiner AP;Aviv A;Lohman K;Liu Y;Ferrucci L;Horvath S
通讯作者：
Horvath S
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S