Innovations in phenotyping of mouse models in the German Mouse Clinic.
Innovations in phenotyping of mouse models in the German Mouse Clinic.
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DOI：
10.1007/s00335-012-9415-1
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发表时间：
2012-10
期刊：
影响因子：
2.5
通讯作者：
de Angelis, Martin Hrabe
中科院分区：
文献类型：
--
作者：
Fuchs, Helmut;Gailus-Durner, Valerie;Neschen, Susanne;Adler, Thure;Afonso, Luciana Caminha;Aguilar-Pimentel, Juan Antonio;Becker, Lore;Bohla, Alexander;Calzada-Wack, Julia;Cohrs, Christian;Dewert, Anna;Fridrich, Barbara;Garrett, Lillian;Glasl, Lisa;Goetz, Alexander;Hans, Wolfgang;Hoelter, Sabine M.;Horsch, Marion;Hurt, Anja;Janas, Eva;Janik, Dirk;Kahle, Melanie;Kistler, Martin;Klein-Rodewald, Tanja;Lengger, Christoph;Ludwig, Tonia;Maier, Holger;Marschall, Susan;Micklich, Kateryna;Moeller, Gabriele;Naton, Beatrix;Prehn, Cornelia;Puk, Oliver;Racz, Ildiko;Raess, Michael;Rathkolb, Birgit;Rozman, Jan;Scheerer, Markus;Schiller, Evelyn;Schrewe, Anja;Steinkamp, Ralph;Stoeger, Claudia;Sun, Minxuan;Szymczak, Wilfried;Treise, Irina;Panesso, Ingrid Liliana Vargas;Vernaleken, Alexandra M.;Willershaeuser, Monja;Wolff-Muscate, Annemarie;Zeh, Ramona;Adamski, Jerzy;Beckers, Johannes;Bekeredjian, Raffi;Busch, Dirk H.;Eickelberg, Oliver;Favor, Jack;Graw, Jochen;Hoefler, Heinz;Hoeschen, Christoph;Katus, Hugo;Klingenspor, Martin;Klopstock, Thomas;Neff, Frauke;Ollert, Markus;Schulz, Holger;Stoeger, Tobias;Wolf, Eckhard;Wurst, Wolfgang;Yildirim, Ali Onder;Zimmer, Andreas;de Angelis, Martin Hrabe
在德国小鼠诊所 (GMC) 的名义下，开发并实施了一个概念，可以在病理生理学和分子水平上更好地了解人类疾病。这包括更好地理解不同器官之间的串扰、基因的多效性以及环境类型和药物的系统影响。在GMC，来自小鼠遗传学和生理学各个领域的专家与临床医生密切合作，在同一屋檐下并肩工作。 GMC 是科学界的一个开放获取平台，通过在双边合作（“自下而上的项目”）中提供表型分析，并作为国际大型生物学项目（“自上而下的项目”）的合作伙伴和推动者。此外，技术开发也是GMC的一大议题。初级和次级筛选的创新技术被开发并应用到表型分析流程中（例如，挥发性有机化合物、VOC 的检测）。
Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations (“bottom-up projects”) and as a partner and driver in international large-scale biology projects (“top-down projects”). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).
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影响因子：
2.5
作者：
Rosemann, Michael;Ivashkevich, Alesia;Graw, Jochen
通讯作者：
Graw, Jochen
DOI：
10.1093/bfgp/elm022
发表时间：
2007-09-01
期刊：
Briefings in Functional Genomics & Proteomics
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Lappalainen, Pekka
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影响因子：
8
作者：
Fan, H.;Chen, L.;Guan, X-Y
通讯作者：
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影响因子：
4.2
作者：
Bergman, Olle;Hakansson, Anna;Nissbrandt, Hans
通讯作者：
Nissbrandt, Hans