Investigating the Circulation of Ebola Viruses in Bats during the Ebola Virus Disease Outbreaks in the Equateur and North Kivu Provinces of the Democratic Republic of Congo from 2018.
Investigating the Circulation of Ebola Viruses in Bats during the Ebola Virus Disease Outbreaks in the Equateur and North Kivu Provinces of the Democratic Republic of Congo from 2018.
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从2018年起，调查了埃博拉病毒疾病爆发期间蝙蝠病毒疾病爆发期间的埃博拉病毒的循环。
DOI：
10.3390/pathogens10050557
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发表时间：
2021-05-04
期刊：
影响因子：
--
通讯作者：
Ahuka Mundeke S
中科院分区：
文献类型：
--
作者：
Lacroix A;Mbala Kingebeni P;Ndimbo Kumugo SP;Lempu G;Butel C;Serrano L;Vidal N;Thaurignac G;Esteban A;Mukadi Bamuleka D;Likofata J;Delaporte E;Muyembe Tamfum JJ;Ayouba A;Peeters M;Ahuka Mundeke S
在31起疫情中，有12起疫情发生在刚果民主共和国，该国受埃博拉病毒病的影响很大。为了更好地了解蝙蝠在埃博拉病毒生态中的作用，我们在最近两次埃博拉疫情爆发期间以及之前爆发过的两个地区对蝙蝠进行了调查。干血斑点检测埃博拉病毒抗体，口腔和直肠拭子使用广谱半套式RT-PCR筛查丝状病毒的存在。2018-2020年，共采集食果蝙蝠892只(88.6%)，食虫蝙蝠115只(11.4%)。总体而言，根据阳性标准，11/925(1.2%)至100/925(10.8%)的蝙蝠对至少一种埃博拉病毒抗原产生抗体。在这四个地点的果蝠以及之前记录的携带埃博拉抗体或RNA的物种中都检测到了抗体。在刚果民主共和国持续爆发埃博拉病毒期间，我们首次检测了大量蝙蝠，但在676只采样的蝙蝠中没有检测到病毒RNA。我们的研究说明了记录蝙蝠作为埃博拉病毒来源的作用的难度，因为它们可能会迅速清除病毒。鉴于埃博拉病毒暴发的频率越来越高，迫切需要对动物宿主进行更多的研究。
With 12 of the 31 outbreaks, the Democratic Republic of Congo (DRC) is highly affected by Ebolavirus disease (EVD). To better understand the role of bats in the ecology of Ebola viruses, we conducted surveys in bats during two recent EVD outbreaks and in two areas with previous outbreaks. Dried blood spots were tested for antibodies to ebolaviruses and oral and rectal swabs were screened for the presence of filovirus using a broadly reactive semi-nested RT-PCR. Between 2018 and 2020, 892 (88.6%) frugivorous and 115 (11.4%) insectivorous bats were collected. Overall, 11/925 (1.2%) to 100/925 (10.8%) bats showed antibodies to at least one Ebolavirus antigen depending on the positivity criteria. Antibodies were detected in fruit bats from the four sites and from species previously documented to harbor Ebola antibodies or RNA. We tested for the first time a large number of bats during ongoing EVD outbreaks in DRC, but no viral RNA was detected in the 676 sampled bats. Our study illustrates the difficulty to document the role of bats as a source of Ebolaviruses as they might clear quickly the virus. Given the increasing frequency of EVD outbreaks, more studies on the animal reservoir are urgently needed.
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影响因子：
11.8
作者：
Kajihara, Masahiro;Hang'ombe, Bernard M.;Takada, Ayato
通讯作者：
Takada, Ayato
影响因子：
11.8
作者：
Gryseels, Sophie;Mbala-Kingebeni, Placide;Ahuka-Mundeke, Steve
通讯作者：
Ahuka-Mundeke, Steve
影响因子：
28.3
作者：
Goldstein T;Anthony SJ;Gbakima A;Bird BH;Bangura J;Tremeau-Bravard A;Belaganahalli MN;Wells HL;Dhanota JK;Liang E;Grodus M;Jangra RK;DeJesus VA;Lasso G;Smith BR;Jambai A;Kamara BO;Kamara S;Bangura W;Monagin C;Shapira S;Johnson CK;Saylors K;Rubin EM;Chandran K;Lipkin WI;Mazet JAK
通讯作者：
Mazet JAK
影响因子：
3.9
作者：
IRWIN, DM;KOCHER, TD;WILSON, AC
通讯作者：
WILSON, AC
影响因子：
56.9
作者：
Bermejo, Magdalena;Rodriguez-Teijeiro, Jose Domingo;Walsh, Peter D.
通讯作者：
Walsh, Peter D.