The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses.
The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses.
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DOI：
10.1038/s41564-018-0227-2
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发表时间：
2018-10
影响因子：
28.3
通讯作者：
Mazet JAK
中科院分区：
文献类型：
--
作者：
Goldstein T;Anthony SJ;Gbakima A;Bird BH;Bangura J;Tremeau-Bravard A;Belaganahalli MN;Wells HL;Dhanota JK;Liang E;Grodus M;Jangra RK;DeJesus VA;Lasso G;Smith BR;Jambai A;Kamara BO;Kamara S;Bangura W;Monagin C;Shapira S;Johnson CK;Saylors K;Rubin EM;Chandran K;Lipkin WI;Mazet JAK
在这里，我们描述了一种新的埃博拉病毒，Bombali病毒（BOMV）在塞拉利昂的无尾蝙蝠（物种：Chaerephonpumilus和Mops condylurus）中检测到的完整基因组。这些蝙蝠被发现栖息在房屋内，这表明人类传播的可能性。我们还表明，病毒糖蛋白可以介导进入人体细胞，但需要进一步的研究，以测试是否暴露实际上已经发生或如果BOMV是致病性的human. Ebola病毒（家庭：丝状病毒科）是非节段，负义，单链RNA病毒。迄今为止已经描述了五个物种，其原型病毒是扎伊尔病毒（EBOV）、本迪布焦病毒（BDBV）、苏丹病毒（SUDV）、塔霍河森林病毒（TAFV）和莱斯顿病毒（RESTV）1。除RESTV外，所有病毒都与人类严重疾病有关。EBOV是第一种被描述的埃博拉病毒，自1976年以来，已经确认了超过25次暴发。最严重的疫情发生在2013-2016年的几内亚、塞拉利昂和利比里亚，估计有28，000人感染，11，325人死亡。最近的埃博拉病毒疫情正在刚果民主共和国爆发。
Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (species: Chaerephonpumilus and Mops condylurus). The bats were found roosting inside houses, indicating the potential for human transmission. We also show that the viral glycoprotein can mediate entry into human cells, though further studies are required to test whether exposure has actually occurred or if BOMV is pathogenic in humans.Ebolaviruses (family: Filoviridae) are non-segmented, negative-sense, single-stranded RNA viruses. Five species have been described to date, for which the prototypic viruses are Zaire virus (EBOV), Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV), and Reston virus (RESTV) 1. With the exception of RESTV, all have been associated with severe disease in humans. EBOV was the first ebolavirus described and since 1976 more than 25 outbreaks have been recognized2. The most significant outbreak occurred in Guinea, Sierra Leone and Liberia in 2013–2016 where an estimated 28,000 humans were infected and 11,325 died3. The most recent EBOV outbreak is ongoing in the Democratic Republic of the Congo.
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影响因子：
64.8
作者：
Cote, Marceline;Misasi, John;Ren, Tao;Bruchez, Anna;Lee, Kyungae;Filone, Claire Marie;Hensley, Lisa;Li, Qi;Ory, Daniel;Chandran, Kartik;Cunningham, James
通讯作者：
Cunningham, James
影响因子：
11.4
作者：
Miller, Emily Happy;Obernosterer, Gregor;Chandran, Kartik
通讯作者：
Chandran, Kartik
影响因子：
3.3
作者：
King, DP;Lie, AR;Stott, JL
通讯作者：
Stott, JL
DOI：
10.1002/prot.10550
发表时间：
2003-01-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子：
--
作者：
Petrey, D;Xiang, ZX;Honig, B
通讯作者：
Honig, B
影响因子：
6.4
作者：
Pourrut, X.;Delicat, A.;Leroy, E. M.
通讯作者：
Leroy, E. M.