An ingestible bacterial-electronic system to monitor gastrointestinal health.
An ingestible bacterial-electronic system to monitor gastrointestinal health.
复制标题
一种可饲养的细菌电子系统，可监测胃肠道健康。
DOI：
10.1126/science.aas9315
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发表时间：
2018-05-25
期刊：
影响因子：
--
通讯作者：
Lu TK
中科院分区：
文献类型：
--
作者：
Mimee M;Nadeau P;Hayward A;Carim S;Flanagan S;Jerger L;Collins J;McDonnell S;Swartwout R;Citorik RJ;Bulović V;Langer R;Traverso G;Chandrakasan AP;Lu TK
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Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.
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影响因子：
64.5
作者：
Lim B;Zimmermann M;Barry NA;Goodman AL
通讯作者：
Goodman AL
DOI：
10.3390/s120100732
发表时间：
2012
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Close D;Xu T;Smartt A;Rogers A;Crossley R;Price S;Ripp S;Sayler G
通讯作者：
Sayler G
影响因子：
17.1
作者：
Courbet, Alexis;Endy, Drew;Bonnet, Jerome
通讯作者：
Bonnet, Jerome
影响因子：
64.8
作者：
Iddan, G;Meron, G;Swain, P
通讯作者：
Swain, P
影响因子：
158.5
作者：
Rockey, DC;Koch, J;McQuaid, K
通讯作者：
McQuaid, K