Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation.
Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation.
复制标题
剖析人类色素沉着进化中选择压力的动态和差异
DOI：
10.1242/bio.056523
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发表时间：
2021-02-09
期刊：
影响因子：
2.4
通讯作者：
He Y
中科院分区：
文献类型：
--
作者：
Huang X;Wang S;Jin L;He Y
人类的色素沉着在人群中是一种高度多样化和复杂的特征，数千年来一直受到学术界和非学术界研究者的特别关注。以前的研究在几个人类色素沉着基因中检测到了选择信号，但很少有研究整合多个基因对人类色素沉着进化的贡献。此外，没有人量化了不同时期和不同种群之间对人类色素沉着的选择压力。在这里，我们用新的方法剖析了不同时期和不同种群之间选择压力的动态和差异。我们使用了17个公开可用的数据集中与人类色素沉着相关的19个基因的基因型数据，并获得了来自世界各地的6个代表性群体的2346个个体的数据。我们的结果量化了自然选择对浅色沉着的强度，不仅在现代欧洲人(0.0259人/代)，而且在原始欧亚人(0.00650人/代)。我们的结果还表明，在一些非洲人群中，与人类深色沉着相关的几个衍生等位基因可能处于正向选择之下。我们的研究首次尝试定量研究人类色素沉着进化过程中不同时间段选择性压力的动态变化。摘要：这项研究开发了一种新的方法来估计随时间推移的选择强度，并将其应用于人类色素沉着的进化。
Human pigmentation is a highly diverse and complex trait among populations and has drawn particular attention from both academic and non-academic investigators for thousands of years. Previous studies detected selection signals in several human pigmentation genes, but few studies have integrated contribution from multiple genes to the evolution of human pigmentation. Moreover, none has quantified selective pressures on human pigmentation over epochs and between populations. Here, we dissect dynamics and differences of selective pressures during different periods and between distinct populations with new approaches. We use genotype data of 19 genes associated with human pigmentation from 17 publicly available datasets and obtain data for 2346 individuals of six representative population groups from across the world. Our results quantify the strength of natural selection on light pigmentation not only in modern Europeans (0.0259/generation) but also in proto-Eurasians (0.00650/generation). Our results also suggest that several derived alleles associated with human dark pigmentation may be under positive directional selection in some African populations. Our study provides the first attempt to quantitatively investigate the dynamics of selective pressures during different time periods in the evolution of human pigmentation. Summary: This study developed a novel approach to estimate selection strength over time and applied it on the evolution of human pigmentation.
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