Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.
Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.
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DOI：
10.1371/journal.pone.0076748
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chiaroni J
中科院分区：
文献类型：
--
作者：
Di Cristofaro J;Pennarun E;Mazières S;Myres NM;Lin AA;Temori SA;Metspalu M;Metspalu E;Witzel M;King RJ;Underhill PA;Villems R;Chiaroni J
尽管位于亚洲的十字路口，但阿富汗人口的基因在很大程度上被忽视了。它目前居住着五个主要民族：普什图人、塔吉克人、哈扎拉人、乌兹别克人和土库曼人。在这里，我们展示了来自我们样本子集的常染色体，来自这5个民族的500多个阿富汗样本的线粒体和Y染色体数据。对来自伊朗、吉尔吉斯斯坦、蒙古的样本和更新后的巴基斯坦样本(HGDP-CEPH)进行了相同的Y染色体分析，补充了阿富汗的这一数据。这里提供的数据被整合到现有的泛欧亚遗传多样性知识中。结构分析和主成分分析以及分子变异分析揭示的遗传变异模式表明，阿富汗人民是由代表欧亚血统不同地理区域的成分拼接而成的。没有中亚特有的主要成分表明，兴都库什人，就像整个中亚种群的基因库一样，是基因流的汇合，而不是原地出现的明显原生种群的来源：这一结论得到了这两个单倍体基因座系统地理的强化。
Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.
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DOI：
10.1073/pnas.0910803106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Chiaroni, Jacques;Underhill, Peter A.;Cavalli-Sforza, Luca L.
通讯作者：
Cavalli-Sforza, Luca L.
影响因子：
10.7
作者：
Chaubey G;Metspalu M;Choi Y;Mägi R;Romero IG;Soares P;van Oven M;Behar DM;Rootsi S;Hudjashov G;Mallick CB;Karmin M;Nelis M;Parik J;Reddy AG;Metspalu E;van Driem G;Xue Y;Tyler-Smith C;Thangaraj K;Singh L;Remm M;Richards MB;Lahr MM;Kayser M;Villems R;Kivisild T
通讯作者：
Kivisild T
影响因子：
3.7
作者：
Bryk, Jaroslaw;Hardouin, Emilie;Myles, Sean
通讯作者：
Myles, Sean
影响因子：
7.7
作者：
Excoffier, Laurent;Lischer, Heidi E. L.
通讯作者：
Lischer, Heidi E. L.
影响因子：
5.2
作者：
Battaglia, Vincenza;Fornarino, Simona;Semino, Ornella
通讯作者：
Semino, Ornella