Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia.

Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia.
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DOI:
10.1310/hct1203-141
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发表时间:
2011-05
影响因子:
--
通讯作者:
Low P
Low P
中科院分区:
医学4区
文献类型:
--
作者:
Chow DC;Wood R;Choi J;Grandinetti A;Gerschenson M;Sriratanaviriyakul N;Nakamoto B;Shikuma C;Low P

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HIV infection has been implicated in dysregulation of the autonomic nervous system. Cross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV. 57 participants were enrolled in 3 groups: 22 were HIV-infected participants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups. There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.
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