FoxM1 as a novel therapeutic target for cancer drug therapy.
FoxM1 as a novel therapeutic target for cancer drug therapy.
复制标题
FoxM1 作为癌症药物治疗的新型治疗靶点。
DOI：
10.7314/apjcp.2015.16.1.23
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Xu XS;Miao RC;Wan Y;Zhang LQ;Qu K;Liu C
背景
目前的癌症治疗主要集中在识别对肿瘤发生至关重要的新靶点。FoxM1作为抗癌靶点是优选的，这是由于其在有丝分裂、细胞周期进展以及导致肿瘤发生的其他信号通路的执行中的重要性。FoxM1部分受癌蛋白或肿瘤抑制因子的调节，这些蛋白或肿瘤抑制因子在人类癌症中经常突变、丢失或过表达。由于维持增殖信号是癌症的重要标志，FoxM1在一系列人类恶性肿瘤中过表达。一项大规模的基因表达分析也确定FoxM1是大多数实体瘤中差异表达的基因。此外，通过考克斯回归分析，在一系列恶性肿瘤中证实过表达的FoxM1与癌症患者的预后相关。因此，已经进行了广泛的研究来探索FoxM1在肿瘤发生中的作用，使其成为抗癌治疗的有吸引力的靶点。据报道，几种抗肿瘤药物靶向或抑制FoxM1在不同癌症中的表达，并且FoxM1的下调也消除了某些癌细胞系中的耐药性，突出了FoxM1在临床上应用的前景。
BACKGROUND
Current cancer therapy mainly focuses on identifying novel targets crucial for tumorigenesis. The FoxM1 is of preference as an anticancer target, due to its significance in execution of mitosis, cell cycle progression, as well as other signal pathways leading to tumorigenesis. FoxM1 is partially regulated by oncoproteins or tumor suppressors, which are often mutated, lost, or overexpressed in human cancer. Since sustaining proliferating signaling is an important hallmark of cancer, FoxM1 is overexpressed in a series of human malignancies. Alarge- scale gene expression analysis also identified FoxM1 as a differentially-expressed gene in most solid tumors. Furthermore, overexpressed FoxM1 is correlated with the prognosis of cancer patients, as verified in a series of malignancies by Cox regression analysis. Thus, extensive studies have been conducted to explore the roles of FoxM1 in tumorigenesis, making it an attractive target for anticancer therapy. Several antitumor drugs have been reported to target or inhibit FoxM1 expression in different cancers, and down-regulation of FoxM1 also abrogates drug resistance in some cancer cell lines, highlighting a promising future for FoxM1 application in the clinic.
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影响因子：
3.9
作者：
Bellelli R;Castellone MD;Garcia-Rostan G;Ugolini C;Nucera C;Sadow PM;Nappi TC;Salerno P;Cantisani MC;Basolo F;Gago TA;Salvatore G;Santoro M
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作者：
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影响因子：
3.3
作者：
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