Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort.
Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort.
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DOI：
10.1136/archdischild-2017-314138
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发表时间：
2018-06
影响因子：
5.2
通讯作者：
Crawley E
中科院分区：
文献类型：
--
作者：
Collin SM;Norris T;Deere KC;Jago R;Ness AR;Crawley E
研究11岁时体力活动与13岁和16岁时慢性失能性疲劳（CDF）的相关性。纵向出生队列。英格兰西南部参加雅芳父母和孩子纵向研究的青少年。我们确定了在13岁和16岁时患有持续时间>6个月的致残性疲劳且原因不明的青少年。总的和中度到剧烈的体力活动和久坐不动的时间在11岁时，通过加速度计测量超过7天的时间。11岁时总体力活动水平高出100计数/分钟与13岁时CDF的几率低25%相关（OR=0.75（95% CI 0.59 - 0.95）），在中度到剧烈活动中花费的监测时间比例增加1%，与CDF的几率降低16%相关（OR=0.84（95% CI 0.69至1.01）），久坐时间增加1小时与CDF几率增加35%相关（OR=1.35（95% CI 1.02至1.79））。13岁时仅持续3-5个月的致残性疲劳与体力活动的相关性较弱，16岁时的CDF与11岁时的体力活动无关。13岁时患有慢性致残性疲劳的儿童在2年前的总体力活动和中度至剧烈体力活动水平较低，久坐时间较多，但这种关联可以用反向因果关系来解释。
To investigate associations of physical activity at age 11 years with chronic disabling fatigue (CDF) at ages 13 and 16 years. Longitudinal birth cohort. South-West England. Adolescents enrolled in the Avon Longitudinal Study of Parents and Children. We identified adolescents who had disabling fatigue of >6 months' duration without a known cause at ages 13 and 16 years. Total and moderate-to-vigorous physical activity and sedentary time at age 11 years were measured by accelerometry over a 7-day period. A total physical activity level 100 counts/min higher at age 11 years was associated with 25% lower odds of CDF at age 13 years (OR=0.75 (95% CI 0.59 to 0.95)), a 1% increase in the proportion of monitored time spent in moderate-to-vigorous activity was associated with 16% lower odds of CDF (OR=0.84 (95% CI 0.69 to 1.01)) and a 1-hour increase in sedentary time was associated with 35% higher odds of CDF (OR=1.35 (95% CI 1.02 to 1.79)). Disabling fatigue of only 3–5 months’ duration at age 13 years had weaker associations with physical activity, and CDF at age 16 years was not associated with physical activity at age 11 years. Children who had chronic disabling fatigue at age 13 years had lower levels of total and moderate-to-vigorous physical activity and more sedentary time 2 years previously, but this association could be explained by reverse causation.
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