The Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein and Its Multiple Roles in mRNA Biogenesis.
The Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein and Its Multiple Roles in mRNA Biogenesis.
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DOI：
10.3389/fmicb.2012.00059
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发表时间：
2012
影响因子：
5.2
通讯作者：
Whitehouse A
中科院分区：
文献类型：
--
作者：
Jackson BR;Noerenberg M;Whitehouse A
调节mRNA生物发生的转录后事件对于控制基因表达至关重要。因此，新生的mRNA通过多聚体RNA-蛋白质复合物被引导，该复合物介导其加帽、剪接、多聚腺苷酸化、核输出，并最终介导其翻译。卡波西肉瘤相关疱疹病毒（KSHV）mRNA转运和积累蛋白（ORF 57）是在所有疱疹病毒中发现的功能保守的蛋白，其在转录后水平上增强病毒基因表达中起关键作用。因此，ORF 57涉及RNA生物发生的多个步骤，包括增强病毒剪接、保护病毒RNA免于降解以增强病毒mRNA核输出和翻译。在这篇综述中，我们强调了KSHV ORF 57在调控转录后事件中的多重作用，这些事件是控制病毒基因表达的基础。
Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA–protein complexes that mediate its capping, splicing, polyadenylation, nuclear export, and ultimately its translation. Kaposi’s sarcoma-associated herpesvirus (KSHV) mRNA transport and accumulation protein, or ORF57, is a functionally conserved protein found in all herpesviruses which plays a pivotal role in enhancing viral gene expression at a post-transcriptional level. As such, ORF57 has been implicated in multiple steps of RNA biogenesis, including augmenting viral splicing, protecting viral RNAs from degradation to enhancing viral mRNA nuclear export and translation. In this review, we highlight the multiple roles of KSHV ORF57 in regulating the post-transcriptional events which are fundamental to the control of virus gene expression.
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