Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA
Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA
复制标题
16 型而非 11 型人乳头瘤病毒 DNA 导致糖皮质激素依赖性致癌转化
作者：
M. M. Pater;G. Hughes;David E. Hyslop;H. Nakshatri;A. Pater
子宫颈鳞状细胞癌是女性最常见的癌症之一。子宫颈人乳头瘤病毒（HPV）感染与宫颈肿瘤发生之间的相关性已得到证实1 -6。最近的研究表明，在70-80%的宫颈肿瘤和肿瘤细胞系中存在并表达整合的HPV 16和18型DNA序列7 -14。有研究表明，除了HPV外，其他因子如激素和烟草制品也是宫颈肿瘤形成的辅助因子（综述见参考文献15）。HPV-16中糖皮质激素反应元件16的存在和表达已被证实17。在这里，我们提供的证据与HPV-16 DNA的组合，但不是HPV-11 DNA的原代细胞的致癌转化，和激活形式的人Ha-ras癌基因只有在糖皮质激素激素地塞米松的存在下。
Squamous cell carcinoma of the uterine cervix is one of the most common cancers among women. Correlation between human papilloma virus (HPV) infection of the uterine cervix and the development of cervical neoplasia has been established1–6. More recent studies have shown the presence and expression of integrated HPV types 16 and 18 DNA sequences in 70–80% of cervical tumours and tumour cell lines7–14. It has been suggested that, in addition to HPVs, other agents such as hormones and tobacco products act as cofactors in cervical neoplasia (for review see ref. 15). The presence and expression of a glucocorticoid-responsive element16 in HPV-16 has been reported17. Here we provide evidence for the oncogenic transformation of primary cells with a combination of HPV-16 DNA, but not HPV-11 DNA, and the activated form of the human Ha-ras oncogene only in the presence of the glucocorticoid hormone dexamethasone.
DOI：
10.1073/pnas.83.13.4680
发表时间：
1986-07-01
影响因子：
11.1
作者：
SMOTKIN, D;WETTSTEIN, FO
通讯作者：
WETTSTEIN, FO
宫颈上皮内瘤变患者人乳头瘤病毒抗原的流行情况。
影响因子：
8.8
作者：
Walker,PG;Singer,A;Dyson,JL;Shah,KV;To,A;Coleman,DV
通讯作者：
Coleman,DV