ANXA2 is correlated with the molecular features and clinical prognosis of glioma, and acts as a potential marker of immunosuppression.
ANXA2 is correlated with the molecular features and clinical prognosis of glioma, and acts as a potential marker of immunosuppression.
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DOI：
10.1038/s41598-021-00366-8
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发表时间：
2021-10-21
影响因子：
4.6
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Ma K;Chen X;Liu W;Yang Y;Chen S;Sun J;Ma C;Wang T;Yang J
最近的研究表明，ANXA 2在许多癌症的发展中很重要，而其在神经胶质瘤相关免疫反应中的作用尚不清楚。本研究旨在全面探讨其在脑胶质瘤中的生物学特性及临床应用价值。我们分析了来自癌症基因组图谱的699个胶质瘤样本作为训练队列，来自中国胶质瘤基因组图谱的325个样本作为验证队列。所有的统计分析和图表都是用R. ANXA 2在高级别胶质瘤、异柠檬酸脱氢酶野生型和间质亚型胶质瘤中显著过表达。ANXA 2是间充质细胞亚型的特异性指标。生存分析显示ANXA 2高表达与患者生存状态差相关，是预后不良的独立因素。进一步的基因本体分析表明ANXA 2主要参与胶质瘤的免疫应答和炎症活动。相关分析显示ANXA 2与HCK、LCK、MHC II、STAT 1、IFN呈正相关，与IgG呈负相关。同时，ANXA 2与肿瘤相关巨噬细胞、调节性T细胞和骨髓源性抑制细胞的浸润呈正相关。ANXA 2是与胶质瘤恶性表型和预后密切相关的生物标志物，在免疫应答、炎症活动和免疫抑制中起重要作用。
Recent studies have shown that ANXA2 is important in the development of many cancers, while its role in glioma-related immune response remains unclear. We aimed to comprehensively investigate its biological characteristics and clinical value in glioma. We analyzed 699 glioma samples from The Cancer Genome Atlas as training cohort and 325 samples from the Chinese Glioma Genome Atlas as validation cohort. All the statistical analyses and figures were generated with R. ANXA2 was overexpressed significantly in high-grade glioma, isocitrate dehydrogenase wild-type and mesenchymal-subtype glioma. ANXA2 was a special indicator of mesenchymal subtype. The survival analysis showed that highly-expressed ANXA2 was related to worse survival status as an independent factor of poor prognosis. Further gene ontology analysis showed that ANXA2 was mainly involved in immune response and inflammatory activities of glioma. Subsequent correlation analysis showed that ANXA2 was positively correlated with HCK, LCK, MHC II, STAT1 and interferon but negatively with IgG. Meanwhile, ANXA2 was positively related to the infiltration of tumor-related macrophages, regulatory T cells and myeloid-derived suppressor cells. Our study revealed that ANXA2 is a biomarker closely related to the malignant phenotype and poor prognosis of glioma, and plays an important role in immune response, inflammatory activity and immunosuppression.
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影响因子：
10.9
作者：
Kim, Victoria M.;Blair, Alex B.;Zheng, Lei
通讯作者：
Zheng, Lei
影响因子：
5.6
作者：
Leong, Leonard;Heng Liang Tan;Choo, Andre
通讯作者：
Choo, Andre
DOI：
10.1073/pnas.1621052114
发表时间：
2017-03-21
影响因子：
11.1
作者：
Marlin, Romain;Pappalardo, Angela;Dechanet-Merville, Julie
通讯作者：
Dechanet-Merville, Julie
DOI：
10.4137/cgm.s27335
发表时间：
2015
期刊：
Cancer growth and metastasis
影响因子：
--
作者：
Kumari S;Malla R
通讯作者：
Malla R
ANXA2、PGAM1、CALR表达水平与胶质瘤分级和预后的相关性
影响因子：
4.1
作者：
Gao, Huasong;Yu, Bin;Gao, Yilu
通讯作者：
Gao, Yilu