MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping.
MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping.
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DOI：
10.1002/mrm.26946
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发表时间：
2018-05
影响因子：
3.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Liu Z;Spincemaille P;Yao Y;Zhang Y;Wang Y
利用脑脊液（CSF）敏感性的最小变化，开发具有一致零参考的定量敏感性作图（QSM）方法。脑室CSF在 地图采用L2正则化来加强分割区域内的CSF磁化率均匀性，其中平均CSF磁化率作为零参考。将CSF均匀性的这种正则化添加到先前QSM方法（形态学启用偶极反转，MEDI）中使用的模型中。因此，所提出的方法被称为MEDI+0，并在数值模拟、多发性硬化（MS）病变和健康受试者的再现性研究中与MEDI进行比较。在数值模拟和在体实验中，MEDI+0不仅降低了脑室CSF内的磁化率变化，而且抑制了侧脑室附近的伪影。在模拟中，与MEDI相比，MEDI+0还在苍白球、黑质、胼胝体和内囊中提供了更准确的定量。MEDI+0测量MS病变易感性与MEDI获得的结果一致。最后，MEDI+0和MEDI均显示出良好且相似的受试者内重现性。心室CSF变化最小的QSM可以提供一致的零参考，同时提高图像质量。
To develop a quantitative susceptibility mapping (QSM) method with a consistent zero reference using minimal variation in cerebrospinal fluid (CSF) susceptibility. The ventricular CSF was automatically segmented on the map. An L2-regularization was employed to enforce CSF susceptibility homogeneity within the segmented region, with the averaged CSF susceptibility as the zero reference. This regularization for CSF homogeneity was added to the model used in a prior QSM method (Morphology Enabled Dipole Inversion, MEDI). Therefore, the proposed method was referred to as MEDI+0 and compared with MEDI in a numerical simulation, in Multiple Sclerosis (MS) lesions and in a reproducibility study in healthy subjects. In both the numerical simulations and in vivo experiments, MEDI+0 not only decreased the susceptibility variation within the ventricular CSF, but also suppressed the artifact near the lateral ventricles. In the simulation, MEDI+0 also provided more accurate quantification compared to MEDI in the globus pallidus, substantia nigra, corpus callosum and internal capsule. MEDI+0 measurements of MS lesion susceptibility were in good agreement with those obtained by MEDI. Finally, both MEDI+0 and MEDI showed good and similar intra-subject reproducibility. QSM with a minimal variation in ventricular CSF is viable to provide a consistent zero reference while improving image quality.
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影响因子：
2.5
作者：
Liu, Tian;Spincemaille, Pascal;de Rochefort, Ludovic;Wong, Richard;Prince, Martin;Wang, Yi
通讯作者：
Wang, Yi
DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
10.6
作者：
Kressler B;de Rochefort L;Liu T;Spincemaille P;Jiang Q;Wang Y
通讯作者：
Wang Y
影响因子：
4.8
作者：
BECKER, G;PEREZ, J;SMITH, RR
通讯作者：
SMITH, RR
影响因子：
19.7
作者：
Chen, Weiwei;Zhu, Wenzhen;Wang, Yi
通讯作者：
Wang, Yi