Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review.

Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review.
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DOI:
10.1016/j.meatsci.2016.04.003
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发表时间:
2016-10
期刊:
影响因子:
7.1
通讯作者:
Du M
Du M
中科院分区:
农林科学1区
文献类型:
--
作者:
Wang B;Yang Q;Harris CL;Nelson ML;Busboom JR;Zhu MJ;Du M

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为了提高动物生产效率,已广泛选择或管理牲畜,以减少脂肪积累和增加瘦肉生长,从而减少肌肉内或大理石纹脂肪含量。为了增强大理石纹,需要更好地了解调节脂肪形成的机制。维生素A最近被证明对脂肪形成的所有阶段都有深远的影响。维甲酸是维生素A的活性代谢物,激活维甲酸受体(RAR)和类维甲酸X受体(RXR),诱导脂肪形成关键调控基因的表观遗传变化。此外,维生素D和叶酸与视黄酸受体相互作用,调节脂肪生成。在这篇综述中,我们讨论了脂肪形成的营养调节,重点是维甲酸及其对关键脂肪形成基因表观遗传修饰的影响。
To improve the efficiency of animal production, livestock have been extensively selected or managed to reduce fat accumulation and increase lean growth, which reduces intramuscular or marbling fat content. To enhance marbling, a better understanding of the mechanisms regulating adipogenesis is needed. Vitamin A has recently been shown to have a profound impact on all stages of adipogenesis. Retinoic acid, an active metabolite of vitamin A, activates both retinoic acid receptors (RAR) and retinoid X receptors (RXR), inducing epigenetic changes in key regulatory genes governing adipogenesis. Additionally, Vitamin D and folates interact with the retinoic acid receptors to regulate adipogenesis. In this review, we discuss nutritional regulation of adipogenesis, focusing on retinoic acid and its impact on epigenetic modifications of key adipogenic genes.
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