Parasite‐induced changes to localized erythrocyte membrane deformability in Plasmodium falciparum cultures
Parasite‐induced changes to localized erythrocyte membrane deformability in Plasmodium falciparum cultures
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恶性疟原虫培养物中寄生虫引起的局部红细胞膜变形能力的变化
DOI：
10.1038/icb.1992.34
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发表时间：
1992
影响因子：
4
通讯作者：
Ross Smith
中科院分区：
文献类型：
--
作者：
KELLIE M. Naumann;Graham L. Jones;A. Saul;Ross Smith
通过将细胞吸入聚碳酸酯过滤器中直径为0.56 μm的孔中，并在固定后用扫描电子显微镜检查，研究了恶性疟原虫寄生虫红细胞内发育对人红细胞膜局部变形性的影响。随着抽吸压力的增加，红细胞膜被挤压到过滤孔中。的突起长度和产生任何变形所需的最小压力的压力依赖性提供的膜剪切和弯曲模量的措施，分别。在滋养体，并在更大程度上，发育的滋养体阶段，宿主细胞膜变形能力显着下降。未感染和环状感染红细胞之间无明显差异。
The effect of intra‐erythrocytic development of the Plasmodium falciparum parasite on local deformability of human erythrocyte membranes was studied by aspiration of cells into 0.56 μm diameter pores in polycarbonate filters and examination, after fixing, with a scanning electron microscope. As the aspiration pressure increased, the erythrocyte membrane was extruded into the filter pores. The pressure dependence of the protrusion length and the minimum pressure required to produce any deformation provided measures of the membrane shear and the bending moduli, respectively. At the trophozoite and, to a greater extent, schizont stage of development, host cell membrane deformability was significantly decreased. There was no appreciable difference between uninfected and ring‐infected erythrocytes.
膜骨架对红细胞变形性、膜材料特性和形状的影响。
影响因子：
3.6
作者：
Mohandas,N;Chasis,JA;Shohet,SB
通讯作者：
Shohet,SB
抗血型糖蛋白 A 的单克隆抗体对疟疾寄生虫入侵的抑制与红细胞膜变形能力的降低相关。
影响因子：
20.3
作者：
Pasvol,G;Chasis,JA;Mohandas,N;Anstee,DJ;Tanner,MJ;Merry,AH
通讯作者：
Merry,AH
影响因子：
56.9
作者：
CRANSTON, HA;BOYLAN, CW;KROGSTAD, DJ
通讯作者：
KROGSTAD, DJ