The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency.
The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency.
复制标题
将围膜综合征视为肾脏缺乏的代谢组理由。
DOI：
10.1155/2020/8568353
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Chen X;Wu C;Liang W;Shen J;Zhuo Z;Hu L;Ruan L;Zhang P;Xu L;Li C;Lin S;Lan J;Ren H;Yao H;Zhao T;Gao B;Lin T;Huang H;Li C
中医在中医辨证分型体系中，通常将围绝经期综合征（PMS）的病因归因于肾虚。然而，这种经典归因的分子基础仍有待研究。研究目的。通过揭示中医治疗肾虚的反应，可以评估经前综合症和肾虚之间的代谢组学联系，以深入了解中医治疗的机制并制定更好的治疗方案。 以自然衰老的大鼠作为经前综合症模型，通过 1H NMR 研究中药治疗肾虚的代谢组学反应。 血浆样品的 1H NMR 代谢组学证据表明，用两种经典的肾虚中药方剂（右归汤和左归汤）治疗，可将疾病模型的代谢状态调节至年轻大鼠的代谢状态。 这些数据支持这样的观点，即肾虚至少在一定程度上是造成经前综合症的原因，相关的处方有助于抑制身体代谢状态的变化，从而缓解这种疾病的症状。
Traditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. Aim of the Study. By unraveling the responses to TCM treatment for kidney deficiency, the metabolomic link between PMS and kidney deficiency can be evaluated for in-depth understanding of the mechanism of TCM treatment and development of better treatment protocols. With naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by 1H NMR. 1H NMR metabolomic evidence of plasma samples demonstrates that treatments with two classical TCM prescriptions for kidney deficiency, decoctions of Yougui and Zuogui, result in modulating the metabolic state of the disease model towards that of rats of younger age. The data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body's metabolic states to alleviate symptoms of the disorder.
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DOI：
10.1016/j.ogc.2011.05.001
发表时间：
2011-09-01
影响因子：
3.2
作者：
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通讯作者：
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DOI：
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发表时间：
2012
期刊：
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DOI：
10.1016/j.ogc.2011.05.005
发表时间：
2011-09-01
影响因子：
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