The brain and brown fat.
The brain and brown fat.
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DOI：
10.3109/07853890.2014.919727
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发表时间：
2015-03
影响因子：
4.4
通讯作者：
López M
中科院分区：
文献类型：
--
作者：
Contreras C;Gonzalez F;Fernø J;Diéguez C;Rahmouni K;Nogueiras R;López M
棕色脂肪组织（BAT）是一个专门的器官，负责产热，维持体温所需的过程。BAT受交感神经系统（SNS）调节，其激活棕色脂肪细胞中的脂解和线粒体解偶联。多年来，BAT被认为只对小型哺乳动物和新生儿有重要作用，但最近的数据表明，BAT对成年人也有作用。基于这一证据，广泛的研究集中在BAT功能上，其中新的分子，如鸢尾素和骨形态发生蛋白，特别是BMP 7和BMP 8B，以及新的中枢因子和新的调节机制，如食欲素和下丘脑典型腹内侧核（VMH）AMP-活化蛋白激酶（AMPK）-SNS-BAT轴，已经被发现并成为对抗肥胖症的潜在药物靶点。在这篇综述中，我们提供了一个概述的复杂的中央调节BAT和不同的神经元细胞群如何协调工作，以维持能量稳态。
Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and mitochondrial uncoupling in brown adipocytes. For many years, BAT was considered to be important only in small mammals and newborn humans, but recent data have shown that BAT is also functional in adult humans. On the basis of this evidence, extensive research has been focused on BAT function, where new molecules, such as irisin and bone morphogenetic proteins, particularly BMP7 and BMP8B, as well as novel central factors and new regulatory mechanisms, such as orexins and the canonical ventomedial nucleus of the hypothalamus (VMH) AMP- activated protein kinase (AMPK)–SNS–BAT axis, have been discovered and emerged as potential drug targets to combat obesity. In this review we provide an overview of the complex central regulation of BAT and how different neuronal cell populations co-ordinately work to maintain energy homeostasis.
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通讯作者：
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