Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women.
Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women.
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DOI：
10.3109/08958378.2014.965559
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发表时间：
2014-12
影响因子：
2.1
通讯作者：
Middlekauff HR
中科院分区：
文献类型：
--
作者：
Ramanathan G;Araujo JA;Gornbein J;Yin F;Middlekauff HR
Smoking is associated with increased fibrinogen and decreased paraoxonase (PON) activity, markers of inflammation and oxidative stress, in patients with coronary artery disease. We tested the hypothesis that the adverse effect of smoking on these biomarkers of inflammation and oxidative stress would be detectable in otherwise healthy young female habitual smokers. Thirty-eight young women participated in the study (n = 20 habitual smokers, n = 18 non-smokers). Fibrinogen, PON-1 activity and HDL oxidant index (HOI) were measured. Mean values of fibrinogen, PON-1 activity and log HOI were not different between the groups. Importantly, however, decreased PON-1 activity (r s = −0.51, p = 0.03) and increased fibrinogen (rs = 0.49, p = 0.04) were significantly correlated with increasing number of cigarettes smoked per day in habitual smokers. Cigarette smoking is associated with a dose-dependent adverse effect on PON-1 activity and fibrinogen in young women, which may have implications for future cardiovascular risk.
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