Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity.
Stereoselective (4 + 3) cycloadditions of allenyl ethers-furans by chiral auxiliaries inducing and evaluation of anti-breast cancer activity.
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手性助剂对联烯基醚-呋喃的立体选择性（4 3）环加成诱导和抗乳腺癌活性评价
DOI：
10.3389/fpls.2022.1087899
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发表时间：
2022
影响因子：
5.6
通讯作者：
Chen, Yang
中科院分区：
文献类型：
--
作者：
Lei, Wenli;Song, Yuyang;Long, Ai;Que, Yanyan;He, Shuzhong;Zhong, Hang;Chen, Yang
关键词：
药用植物是药物发现的天然产物宝库。具有七元环骨架的最活跃分子对结构提出了挑战。研究了手性助剂诱导烯基醚与取代呋喃之间的立体选择性（4 + 3）环加成反应。结果显示了显著的立体选择性和区域选择性。通过在酸性条件下去除手性助剂，合成了氧取代七元环框架的光学环加合物。新化合物对T47D细胞的抗增殖活性显示出中等的抗增殖作用。
The medicinal plants were wildly library of natural products in drug discovery. The most active molecules with seven-membered rings skeleton represent a challenge for construction. A stereoselectivity (4 + 3) cycloadditions between allenyl ethers and substituted furans induced by chiral auxiliaries has been investigated. And the results showed significant stereoselectivities and regioselectivities. The optical cycloadducts with an oxygen-substituted seven-membered ring framework were generated by removing chiral auxiliaries under acidic conditions. The antiproliferative activity of the novel compounds displayed moderate antiproliferative effects toward T47D cells.
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影响因子：
1.8
作者：
Duh, CY;Wang, SK;Chiang, MY
通讯作者：
Chiang, MY
影响因子：
15
作者：
Harrington, PE;Murai, T;Tius, MA
通讯作者：
Tius, MA
影响因子：
5.2
作者：
Sáez, JA;Arnó, M;Domingo, LR
通讯作者：
Domingo, LR
影响因子：
5.2
作者：
Harrington, PE;Tius, MA
通讯作者：
Tius, MA
DOI：
10.1111/j.1095-8339.1977.tb01163.x
发表时间：
1977-01-01
影响因子：
2.4
作者：
EVANS, FJ;KINGHORN, AD
通讯作者：
KINGHORN, AD