Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals.
Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals.
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DOI：
10.1111/j.1532-5415.2011.03570.x
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发表时间：
2011-09
影响因子：
6.3
通讯作者：
Landi F
中科院分区：
文献类型：
--
作者：
Giovannini S;Onder G;Liperoti R;Russo A;Carter C;Capoluongo E;Pahor M;Bernabei R;Landi F
衰老的特征是慢性低度炎症，已发现与老年人的死亡风险有关。本研究的目的是调查白细胞介素-6（IL-6）、C-反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）蛋白水平是否可预测社区老年人的全因死亡率。数据来自Sirente地理区域的老龄化和长寿研究（ilSIRENTE研究），这是一项前瞻性队列研究，收集了生活在意大利山区社区的80岁及以上的个人（n=362）的信息。主要结果是随访4年后死亡的风险比。根据3种炎症标志物的中位数（IL-6：2.08 pg/mL; TNF-α：1.43 pg/mL和CRP：3.08 mg/L）对参与者进行分类。此外，还创建了炎症的综合总结评分。在4年的随访期间，共发生150例死亡。在未调整的模型中，3种标志物中的每一种的高水平与死亡率增加相关。在调整潜在的混杂因素后，高水平的IL-6和CRP与死亡风险显著增加相关（HR，2.18; 95%CI分别为1.29-3.69和2.58; 95%CI 1.52-4.40）;而TNF-α蛋白水平与死亡率之间的相关性失去了显著性（1.26; 95%CI：0.74 - 2.15）。炎症综合评分与死亡率密切相关，所有三种炎症标志物均高于中位数的个体估计风险最高。低水平的炎症标志物与老年人更好的生存率相关，与年龄和其他临床和功能变量无关。
Aging is characterized by a chronic low-grade inflammation that has been found to be related to mortality risk in older persons. The aim of the present study was to investigate whether interleukin-6 (IL-6), C-reactive protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) protein levels predict all-cause mortality in a sample of older persons living in the community. Data are from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study), a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=362). The main outcome was the hazard ratio of death after four years of follow-up. Participants were classified according to the median value of the 3 inflammatory markers (IL-6: 2.08 pg/mL; TNF-α: 1.43 pg/mL and CRP: 3.08 mg/L). In addition, a composite summary score of inflammation was created. A total of 150 deaths occurred during a 4-year follow-up. In the unadjusted model, high levels of each of the 3 markers were associated with increased mortality. After adjusting for potential confounders, high levels of IL-6 and CRP were associated with a significantly increased risk of death (HR, 2.18; 95% CI 1.29–3.69 and 2.58; 95% CI 1.52–4.40, respectively); whereas the association between TNF-α protein levels and mortality lost significance (1.26; 95% CI: 0.74 to 2.15). The composite summary score of inflammation was strongly associated with mortality, with the highest risk estimated for individuals with all three inflammatory markers above the median. Low levels of inflammatory markers are associated with better survival in elderly, independently of age and other clinical and functional variables.
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影响因子：
20.3
作者：
PELLINIEMI, TT;IRJALA, K;LAHTINEN, R
通讯作者：
LAHTINEN, R
影响因子：
5.9
作者：
Harris, TB;Ferrucci, L;Wallace, R
通讯作者：
Wallace, R
DOI：
10.1016/0735-1097(95)00589-7
发表时间：
1996-04-01
影响因子：
24
作者：
TorreAmione, G;Kapadia, S;Mann, DL
通讯作者：
Mann, DL
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
15.9
作者：
Pepys, MB;Hirschfield, GM
通讯作者：
Hirschfield, GM