The soluble biomarker calprotectin (an S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab.
The soluble biomarker calprotectin (an S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab.
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DOI：
10.1186/ar3503
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发表时间：
2011
影响因子：
4.9
通讯作者：
Kvien TK
中科院分区：
文献类型：
--
作者：
Hammer HB;Fagerhol MK;Wien TN;Kvien TK
钙卫蛋白（MRP 8/MRP 14，S100 A8/A9）与类风湿性关节炎（RA）患者的疾病活动相关。超声检查（US）是评价滑膜炎的可靠方法（B型（BM）和能量多普勒（PD））。本研究的目的是探讨在RA患者中钙卫蛋白与全面超声检查之间的相关性，以及抗TNF治疗期间钙卫蛋白与其他炎症标志物相比的反应性。在基线和1、3、6和12个月后，通过US（78个关节、36个肌腱/肌腱组和2个滑囊的BM和PD（半定量评分0 - 3））和临床纵向检查了共计20例开始阿达木单抗治疗的RA患者。通过相关性和线性回归分析探讨US总分与炎症标志物钙卫蛋白、血清淀粉样蛋白A（SAA）、CRP和ESR之间的关系，并通过标准化反应均值（SRM）评估对治疗的反应。治疗后炎症指标、临床检查及超声总积分均有改善（P < 0.001）。在炎症标志物中，钙卫蛋白与总BM和PD总分的相关系数最高（BM的中位数（范围）为0.59（0.37 - 0.76），PD为0.56（0.38 - 0.72））。钙卫蛋白与关节计数减少的US总评分之间的相关性甚至更高。在线性回归分析中，钙卫蛋白对总US总分有相当大的贡献（P = 0.001至0.031），在炎症标志物中，钙卫蛋白的SRM最高（1个月时为0.84）。钙卫蛋白与美国综合评估的总分相关，并对抗TNF治疗期间的变化有反应。因此，检查这种白细胞蛋白可能是额外的价值评估类风湿关节炎患者的生物治疗。
Calprotectin (MRP8/MRP14, S100A8/A9) is associated with disease activity in patients with rheumatoid arthritis (RA). Ultrasonography (US) is a reliable method for evaluation of synovitis (B-mode (BM) and power Doppler (PD)). The present objectives were to explore in RA patients the associations between calprotectin and a comprehensive US examination, as well as the responsiveness of calprotectin compared to other inflammatory markers during anti-TNF treatment. A total of 20 RA patients starting treatment with adalimumab were examined longitudinally by US (BM and PD (semi-quantitative scores 0 to 3) of 78 joints, 36 tendons/tendon groups and 2 bursae) and clinically at baseline and after 1, 3, 6 and 12 months. Associations between the US sum scores and the inflammatory markers calprotectin, serum amyloid A (SAA), CRP and ESR were explored by correlation and linear regression analyses, and the response to treatment was assessed by Standardized Response Mean (SRM). The inflammatory markers, clinical examinations and US sum scores improved during treatment (P < 0.001). Of the inflammatory markers, calprotectin had the highest correlation coefficients with the total BM and PD sum scores (median (range) 0.59 (0.37 to 0.76) for BM and 0.56 (0.38 to 0.72) for PD). Even higher correlations were found between calprotectin and sum US scores of reduced number of joint counts. Calprotectin made a considerable contribution to total US sum scores in the linear regression analyses (P = 0.001 to 0.031) and among the inflammatory markers, calprotectin had the highest SRM (0.84 at one month). Calprotectin was associated with the sum scores from a comprehensive US assessment and was responsive to change during anti-TNF treatment. Thus, examination of this leukocyte protein could be of additional value in the assessment of RA patients on biologic treatment.
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影响因子：
4.9
作者：
Hammer HB;Kvien TK
通讯作者：
Kvien TK
影响因子：
120.7
作者：
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27.4
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通讯作者：
Haavardsholm, Espen A.
影响因子：
27.4
作者：
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通讯作者：
Kvien, T. K.
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