Comparisons of 7- to 78-joint ultrasonography scores: all different joint combinations show equal response to adalimumab treatment in patients with rheumatoid arthritis.
Comparisons of 7- to 78-joint ultrasonography scores: all different joint combinations show equal response to adalimumab treatment in patients with rheumatoid arthritis.
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DOI：
10.1186/ar3341
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发表时间：
2011-05-27
影响因子：
4.9
通讯作者：
Kvien TK
中科院分区：
文献类型：
--
作者：
Hammer HB;Kvien TK
主要目的是探索关节、肌腱和滑囊的全面超声（US）评估与先前描述的关节计数减少（7、12、28和44关节评分）之间的相关性，以及评估生物治疗期间这些不同US关节组合变化的敏感性。在基线和开始阿达木单抗治疗后1、3、6和12个月，使用78个关节、36个肌腱/肌腱组和2个滑囊的半定量（0 - 3）评分（下文描述为78关节评分），通过US（B模式（BM）和能量多普勒（PD））检查了20例类风湿性关节炎（RA）患者。生成不同关节组合的BM和PD评分。关节评分降低与所有检查的78个关节评分具有高度相关系数（BM范围为0.79至0.99，PD范围为0.77至0.99，均P < 0.001），所有不同关节组合的BM和PD评分总和在随访期间均显著改善（P ≤ 0.05至0.001）。减少的关节组合与78关节评分高度相关。此外，目前探索的所有联合组合对生物处理反应良好。这表明，一种专注于少数关节和肌腱的方法可以提供与全面的US检查相同的关于RA患者炎症活动的信息。关节和肌腱的最佳组合，一个有效的，可靠的和可行的超声测量应进一步探讨，以确定一个US评分的后续RA患者的生物治疗。
The primary objectives were to explore the associations between a comprehensive ultrasonographic (US) assessment of joints, tendons and bursae and previously described reduced joint counts (7-, 12-, 28- and 44-joint score) as well as to assess the sensitivity to change of these different US joint combinations during biological treatment. Twenty patients with rheumatoid arthritis (RA) were examined by US (B-mode (BM) and power Doppler (PD)) with use of a semi-quantitative (0 to 3) score of 78 joints, 36 tendons/tendon groups and two bursae (hereafter described as the 78-joint score) at baseline and 1, 3, 6 and 12 months after initiating treatment with adalimumab. BM and PD scores for the different joint combinations were generated. The reduced joint scores had high correlation coefficients with the 78-joint score at all examinations (range 0.79 to 0.99 for BM and 0.77 to 0.99 for PD, each P < 0.001) and sum BM and PD scores of all the different joint combinations improved significantly during follow-up (P ≤ 0.05 to 0.001). The reduced joint combinations were highly associated to the 78-joint score. Furthermore, all the joint combinations presently explored responded well to biological treatment. This indicates that an approach focusing on few joints and tendons gives equivalent information about the inflammatory activity in RA patients as a comprehensive US examination. The optimal combination of joints and tendons for a valid, reliable and feasible US measurement should be further explored to define a US score for follow-up of RA patients on biological treatment.
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影响因子：
3.9
作者：
Jousse-Joulin, Sandrine;d'Agostino, Maria Antonietta;Saraux, Alain
通讯作者：
Saraux, Alain
影响因子：
5.5
作者：
Ellegaard, Karen;Torp-Pedersen, Soren;Bliddal, Henning
通讯作者：
Bliddal, Henning
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影响因子：
4.9
作者：
Szkudlarek, Marcin;Klarlund, Mette;Narvestad, Eva;Court-Payen, Michel;Strandberg, Charlotte;Jensen, Karl E.;Thomsen, Henrik S.;Ostergaard, Mikkel
通讯作者：
Ostergaard, Mikkel
影响因子：
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作者：
Naredo, Esperanza;Moeller, Ingrid;Garrido, Jesus
通讯作者：
Garrido, Jesus
影响因子：
5.9
作者：
Szkudlarek, M;Court-Payen, M;Ostergaard, M
通讯作者：
Ostergaard, M