The multifaceted protease-anti-protease imbalance in COVID-19.
The multifaceted protease-anti-protease imbalance in COVID-19.
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DOI：
10.1016/j.ebiom.2022.103973
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发表时间：
2022-04
期刊：
影响因子：
11.1
通讯作者：
Serban KA
中科院分区：
文献类型：
--
作者：
Goel K;Serban KA
在这一期的eBioMedicine中，McElvaney博士及其同事报告了疾病过程以及靶向IL-6信号传导的疗法改变了中度至重度COVID-19 ARDS中的蛋白酶/抗蛋白酶平衡。1作者使用COVID-19受试者的相关临床样本（血浆、气管抽吸物和肺），测量了在COVID-19治疗中使用的IL-6受体拮抗剂托珠单抗（tocilizumab）治疗前后α-1抗胰蛋白酶（AAT）水平及其对中性粒细胞弹性蛋白酶（NE）的活性。1强烈的炎症和肺泡-毛细血管屏障的破坏是ARDS肺损伤的关键特征，并且与初始损伤无关，初始损伤可以是肺特异性的（细菌性肺炎或COVID-19）或全身性的（创伤或非肺脓毒症）。在ARDS患者中，炎症是由嗜中性粒细胞占优势的空域募集和与病原体相互作用后由中性粒细胞或气道和远端肺的结构细胞分泌的蛋白酶、细胞因子和代谢物的促炎环境（例如SARS-CoV-2）驱动的。
In this issue of eBioMedicine, Dr. McElvaney and colleagues report altered protease/anti-protease balance in moderate to severe COVID-19 ARDS by the disease processes as well as therapies targeting IL-6 signaling. 1 The authors use relevant clinical samples (plasma, tracheal aspirate, and lungs) of COVID-19 subjects to measure alpha-1 antitrypsin (AAT) level and its activity against the protease neutrophil elastase (NE) before and after tocilizumab, an IL-6 receptor antagonist used in COVID-19 treatment. 1Robust inflammation and disruption of alveolar-capillary barrier are key features of ARDS lung injury and are independent of the initial insult, which can either be lung-specific (bacterial pneumonia or COVID-19) or systemic (trauma or non-pulmonary sepsis). In ARDS patients the inflammation is driven by neutrophil-predominant airspace recruitment and the pro-inflammatory milieu of proteases, cytokines, and metabolites secreted by the neutrophils or the structural cells of the airways and distal lung after interaction with the pathogen (eg SARS-CoV-2).
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影响因子：
11.1
作者：
McElvaney OF;Asakura T;Meinig SL;Torres-Castillo JL;Hagan RS;Gabillard-Lefort C;Murphy MP;Thorne LB;Borczuk A;Reeves EP;Zumwalt RE;Mikami Y;Carroll TP;Okuda K;Hogan G;McElvaney OJ;Clarke J;McEvoy NL;Mallon PW;McCarthy C;Curley G;Wolfgang MC;Boucher RC;McElvaney NG
通讯作者：
McElvaney NG
DOI：
10.1164/rccm.202005-1583oc
发表时间：
2020-09-15
影响因子：
24.7
作者：
McElvaney, Oliver J.;McEvoy, Natalie L.;McElvaney, Noel G.
通讯作者：
McElvaney, Noel G.
影响因子：
16.6
作者：
Wettstein L;Weil T;Conzelmann C;Müller JA;Groß R;Hirschenberger M;Seidel A;Klute S;Zech F;Prelli Bozzo C;Preising N;Fois G;Lochbaum R;Knaff PM;Mailänder V;Ständker L;Thal DR;Schumann C;Stenger S;Kleger A;Lochnit G;Mayer B;Ruiz-Blanco YB;Hoffmann M;Sparrer KMJ;Pöhlmann S;Sanchez-Garcia E;Kirchhoff F;Frick M;Münch J
通讯作者：
Münch J
影响因子：
9.6
作者：
Polverino, Eva;Rosales-Mayor, Edmundo;Torres, Antoni
通讯作者：
Torres, Antoni
DOI：
10.1016/j.trsl.2020.12.008
发表时间：
2021-06
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Bime C;Casanova NG;Nikolich-Zugich J;Knox KS;Camp SM;Garcia JGN
通讯作者：
Garcia JGN