5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study.
5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study.
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5-氟尿嘧啶和青光眼滤过手术。
DOI：
10.1016/s0161-6420(86)33542-5
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发表时间：
1986
期刊：
影响因子：
13.7
通讯作者：
Rockwood,EJ
中科院分区：
文献类型：
--
作者：
Heuer,DK;Parrish2nd,RK;Gressel,MG;Hodapp,E;Desjardins,DC;Skuta,GL;Palmberg,PF;Nevárez,JA;Rockwood,EJ
95例患者（104只眼）入组了一项初步研究，在手术效果不佳的眼睛中进行滤过手术后结膜下注射5-氟尿嘧啶（5-FU）。对84名患者进行了至少6个月的随访，其中4名患者被排除在手术结果分析之外，因为他们在滤过手术后6个月内患有视网膜脱离。其余80例患者的初始5-FU手术均获得成功（未进行或推荐进一步的青光眼手术，眼内压[IOP]为21 mmHg或更低，使用眼部扩张药物，或25 mmHg或更低，不使用眼部扩张药物），48只无晶状体眼中的33只（68%）患有非新生血管性青光眼，16只有晶状体眼中13只（81%）为滤过手术失败后的非新生血管性青光眼，12只（75%）为新生血管性青光眼。成功眼的随访时间为6 ~ 34个月（平均值± SD = 18.5 ± 7.5）。非新生血管性青光眼无晶状体眼48只眼中38只眼（79%）视力保持在术前水平的一行内或提高，非新生血管性青光眼有晶状体眼16只眼中11只眼（69%）在滤过手术不成功后，NVG 16只眼中12只眼（75%）视力保持在术前水平的一行内或提高。104只眼睛的初始5-FU手术并发以下情况：角膜上皮缺损（50%）;结膜伤口和缝合道渗漏（36%; 2%接受手术修复）;脉络膜上膜破裂（9%）;视网膜脱离（3%）;上皮下角膜瘢痕（3%）;眼内炎（2%）;和恶性青光眼（1%）。作者的印象是，术后结膜下5-FU增加了手术效果差的眼睛在滤过手术后实现IOP控制的可能性;然而，需要进行随机临床试验来证实这一印象。
Ninety-five patients (104 eyes) were enrolled in a pilot study of subconjunctival 5-fluorouracil (5-FU) injections after filtering surgery in eyes with poor surgical prognoses. At least a six-month follow-up was available on 84 patients, of whom four were excluded from the analysis of surgical outcome because they suffered retinal detachments within six months of their filtering surgery. The initial 5-FU procedures on the remaining 80 patients were successful (no further glaucoma surgical procedures were either performed or recommended, and the intraocular pressures [IOPs] were either 21 mmHg or lower with ocular hypotensive medication[s] or 25 mmHg or lower without ocular hypotensive medication) in 33 (68%) of the 48 aphakic eyes with non-neovascular glaucomas, 13 (81 %) of the 16 phakic eyes with non-neovascular glaucomas after unsuccessful filtering surgery, and 12 (75%) of the 16 eyes with neovascular glaucoma (NVG). The follow-up on the successful eyes ranged from 6 to 34 months (mean ± SD = 18.5 ± 7.5). The visual acuities remained within one line of their preoperative levels or improved in 38 (79%) of the 48 aphakic eyes with non-neovascular glaucoma, 11 (69%) of the 16 phakic eyes with nonneovascular glaucoma after unsuccessful filtering surgery, and 12 (75%) of the 16 eyes with NVG. The initial 5-FU procedures on the 104 eyes were complicated by the following: corneal epithelial defects (50%); conjunctival wound and suture tract leaks (36%; 2% underwent surgical repair); suprachoroidal hemorrhages (9%); retinal detachments (3%); subepithelial corneal scarring (3%); endophthalmitis (2%); and malignant glaucoma (1 %). It is the authors' impression that postoperative subconjuctival 5-FU increases the likelihood of achieving IOP control after filtering surgery in eyes with poor surgical prognoses; however, a randomized clinical trial is necessary to confirm this impression.
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兔结膜下注射 14C-氟尿嘧啶的眼内渗透。
DOI：
--
发表时间：
1979
期刊：
A M A Archives of Ophthalmology
影响因子：
--
作者：
J. Rootman;J. Tisdall;G. Gudauskas;A. Ostry
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A. Ostry
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DOI：
--
发表时间：
1983
期刊：
Nippon Ganka Gakkai zasshi
影响因子：
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作者：
Z. Inaba
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Z. Inaba
前房管分流至环带治疗新生血管性青光眼。
DOI：
--
发表时间：
1982
期刊：
Ophthalmology (Rochester, Minn.)
影响因子：
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作者：
S. Schocket;V. Lakhanpal;Richard D. Richards
通讯作者：
Richard D. Richards
[关于“出血性”青光眼的手术治疗]。
DOI：
--
发表时间：
1965
期刊：
Klinische Monatsblätter für Augenheilkunde
影响因子：
--
作者：
K. Mueller
通讯作者：
K. Mueller
无晶状体眼型青光眼小梁切除术的临床评价
影响因子：
3.1
作者：
S. Sharma;T. Singh
通讯作者：
T. Singh