Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence.
Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence.
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DOI：
10.1007/s00213-008-1225-5
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发表时间：
2008-11
影响因子：
3.4
通讯作者：
Frost, J. James
中科院分区：
文献类型：
--
作者：
Gorelick, David A.;Kim, Yu Kyeong;Bencherif, Badreddine;Boyd, Susan J.;Nelson, Richard;Copersino, Marc L.;Dannals, Robert F.;Frost, J. James
关键词：
Cocaine users have increased regional brain mu-opioid receptor (mOR) binding which correlates with cocaine craving. The relationship of mOR binding to relapse is unknown. To evaluate regional brain mOR binding as a predictor of relapse to cocaine use. Fifteen non-treatment-seeking, adult cocaine users were housed on a closed research ward for 12 weeks of monitored abstinence, then followed for up to one year after discharge. Regional brain mOR binding was measured after one and 12 weeks using positron emission tomography (PET) with [11C]carfentanil (a selective mOR agonist). Time to first cocaine use (lapse) and to first two consecutive days of cocaine use (relapse) after discharge was based on self-report and urine toxicology. A shorter interval before relapse was associated with increased mOR binding in frontal and temporal cortical regions at one and 12 weeks of abstinence (P’s < 0.001) and with a lesser decrease in binding between one and 12 weeks (P’s < 0.0008). There were significant positive correlations between mOR binding at 12 weeks and % days of cocaine use during first month after relapse (P’s < 0.002). In multiple linear regression analysis, mOR binding contributed significantly to the prediction of time to relapse (R2 = 0.79, P < 0.001), even after accounting for clinical variables. Increased brain mOR binding in frontal and temporal cortical regions is a significant independent predictor of time to relapse to cocaine use, suggesting an important role for the brain endogenous opioid system in cocaine addiction.
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影响因子：
1.3
作者：
FROST, JJ;WAGNER, HN;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
4.4
作者：
Azaryan, AV;Clock, BJ;Cox, BM
通讯作者：
Cox, BM
DOI：
10.1016/0169-328x(92)90178-e
发表时间：
1992-07-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
BRANCH, AD;UNTERWALD, EM;KREEK, MJ
通讯作者：
KREEK, MJ
影响因子：
6
作者：
Donovan, DM
通讯作者：
Donovan, DM
影响因子：
2.7
作者：
Hser, YI;Maglione, M;Boyle, K
通讯作者：
Boyle, K