Biomechanical characterization of isolated epineurial and perineurial membranes of rabbit sciatic nerve.
Biomechanical characterization of isolated epineurial and perineurial membranes of rabbit sciatic nerve.
复制标题
兔坐骨神经离体神经外膜和神经周围膜的生物力学特征。
DOI：
10.1016/j.jbiomech.2022.111058
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发表时间：
2022
影响因子：
2.4
通讯作者：
D. Tyler
中科院分区：
文献类型：
--
作者：
S. Koppaka;A. Hess;D. Tyler
用于有效、长期整合到神经组织中的界面装置的设计取决于神经膜的生物力学性质。在周围神经内，用于连接的两个相关结缔组织层是神经外膜和神经束膜。以前的工作已经报道了穿透整个神经所需的力，但是没有报道神经外膜和神经束膜之间的机械差异。将电极放置在神经内的神经内电极的设计需要个体组织的力学知识。本研究定量的杨氏模量和极限应变的神经束膜和神经外膜分别。我们还测量了单独穿透每个组织所需的力。我们使用定制的微拉伸测试设备来测量杨氏模量值。测得神经外膜和神经束膜的杨氏模量分别为0.4 ± 0.1MPa和3.0 ± 0.3MPa。我们还测量了以2 mm/s的速度将直径为100 µm的钝头和锋利不锈钢探针插入分离的神经外膜组织和神经束膜组织所需的力。这些数据为选择最适合组织特性的长期植入物材料提供了额外指南。这些结果将指导神经接口设计，使得电极可以通过单独的神经外膜或神经外膜和神经束膜放置。
Design of interface devices for effective, long-term integration into neural tissue is dependent on the biomechanical properties of the nerve membranes. Within the peripheral nerve, the two relevant connective tissue layers for interfacing are the epineurium and perineurium. Previous work has reported the forces needed to penetrate the whole nerve, but the mechanical differences between epineurium and perineurium were not reported. Design of intraneural electrodes that place electrodes within the nerve requires knowledge of the mechanics of individual tissues. This study quantified the Young’s moduli and ultimate strains of the perineurium and the epineurium separately. We also measured the forces necessary to penetrate each tissue in isolation. We used a custom-built microtensile testing device to measure the Young’s modulus values. The measured Young’s moduli of the epineurium and the perineurium was 0.4 ± 0.1 MPa and 3.0 ± 0.3 MPa, respectively. We also measured the force required for blunt and sharp stainless steel, 100 µm diameter probes to be inserted into isolated epineurial tissue and perineurial tissue at 2 mm/s. These data provide additional guidelines for selection of materials for long-term implants that best match the tissue properties. The results will guide neural interface design such that electrodes can be placed through either the epineurium alone or both the epineurium and perineurium.
人类视神经鞘的双层力学。
影响因子：
2
作者：
Shin,Andrew;Park,Joseph;Le,Alan;Poukens,Vadims;Demer,JosephL
通讯作者：
Demer,JosephL