Bilaminar Mechanics of the Human Optic Nerve Sheath.
Bilaminar Mechanics of the Human Optic Nerve Sheath.
复制标题
人类视神经鞘的双层力学。
DOI：
10.1080/02713683.2019.1701689
复制
发表时间：
2020
影响因子：
2
通讯作者：
Demer,JosephL
中科院分区：
文献类型：
--
作者：
Shin,Andrew;Park,Joseph;Le,Alan;Poukens,Vadims;Demer,JosephL
目的成人视神经鞘是由内层和外层组成的双层结构。由于ON和鞘施加张力的地球仪在大角度内收，因为这些结构的内直肌的反作用力传递到地球仪，本研究探讨了人类ON sheath.Materials和MethodsBiomechanical表征进行了12对新鲜的，死后成年人的眼睛在ON鞘标本。一些ON鞘管样本被完全测试，而另一些则被分为IL和OL。在生理温度和湿度下的单轴拉伸载荷被用来表征作为杨氏模量的线性近似，和使用奥格登公式的超弹性非线性行为。微压痕是通过对小而硬的球体施加小的压缩变形来进行的。相同鞘标本石蜡包埋，切片在10微米厚，和染色货车Gieson的染色解剖correlation.ResultsMean（±标准误差的平均值，SEM）拉伸杨氏模量的内鞘在19.8 ± 1.6 MPa显着超过OL在9.7 ± 1.2 MPa;整个鞘显示中间模量为15.4 ± 1.1 MPa。在压缩下，内鞘管比外鞘管更硬（7.9 ± 0.5 vs 5.2 ± 0.5 kPa）且更粘（150.8 ± 10.6 vs 75.6 ± 6 kPa s）。内鞘有更密集的弹性蛋白纤维比外鞘，与更大的stiffness.ConclusionsWe的结论，最大的拉伸刚度发生在弹性蛋白丰富的ON鞘IL插入附近的筛板，其中在鞘内收系绳期间施加的张力可以集中在邻近的ON头。
Purpose/AimThe adult human optic nerve (ON) sheath has recently been recognized to be bilaminar, consisting of inner layer (IL) and outer layer (OL). Since the ON and sheath exert tension on the globe in large angle adduction as these structures transmit reaction force of the medial rectus muscle to the globe, this study investigated the laminar biomechanics of the human ON sheath.Materials and MethodsBiomechanical characterization was performed in ON sheath specimens from 12 pairs of fresh, post-mortem adult eyes. Some ON sheath specimens were tested completely, while others were separated into IL and OL. Uniaxial tensile loading under physiological temperature and humidity was used to characterize a linear approximation as Young’s modulus, and hyperelastic non-linear behavior using the formulation of Ogden. Micro-indentation was performed by imposing small compressive deformations with small, hard spheres. Specimens of the same sheaths were paraffin embedded, sectioned at 10 micron thickness, and stained with van Gieson’s stain for anatomical correlation.ResultsMean (± standard error of the mean, SEM) tensile Young’s modulus of the inner sheath at 19.8 ± 1.6 MPa significantly exceeded that for OL at 9.7 ± 1.2 MPa; the whole sheath showed intermediate modulus of 15.4 ± 1.1 MPa. Under compression, the inner sheath was stiffer (7.9 ± 0.5 vs 5.2 ± 0.5 kPa) and more viscous (150.8 ± 10.6 vs 75.6 ± 6 kPa s) than outer sheath. The inner sheath had denser elastin fibers than outer sheath, correlating with greater stiffness.ConclusionsWe conclude that maximum tensile stiffness occurs in the elastin-rich ON sheath IL that inserts near the lamina cribrosa where tension in the sheath exerted during adduction tethering may be concentrated adjacent the ON head.
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视觉搜索多个目标期间眼球扫视运动的时间。
影响因子：
1.8
作者：
Wu,Chia-Chien;Kowler,Eileen
通讯作者：
Kowler,Eileen
影响因子：
4.4
作者：
Shin, Andrew;Yoo, Lawrence;Demer, Joseph L.
通讯作者：
Demer, Joseph L.
影响因子：
4.1
作者：
Albon, J;Karwatowski, WSS;Duance, VC
通讯作者：
Duance, VC
影响因子：
4.4
作者：
Sibony, Patrick A.
通讯作者：
Sibony, Patrick A.
年龄硬化组织和眼压对视神经损伤的影响。
DOI：
10.3970/mcb.2012.009.157
发表时间：
2012
期刊：
Molecular & cellular biomechanics : MCB
影响因子：
--
作者：
L. K. Leung;M. Ko;D. C. Lam
通讯作者：
D. C. Lam