Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia.

Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia.
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DOI:
10.1021/ol300657h
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发表时间:
2012-04-20
期刊:
影响因子:
5.2
通讯作者:
Kinghorn AD
Kinghorn AD
中科院分区:
化学1区
文献类型:
--
作者:
Pan L;Terrazas C;Lezama-Davila CM;Rege N;Gallucci JC;Satoskar AR;Kinghorn AD

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Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolide A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs).
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