Cardiovascular disease mortality and serum carotenoid levels: a Japanese population-based follow-up study.
Cardiovascular disease mortality and serum carotenoid levels: a Japanese population-based follow-up study.
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DOI：
10.2188/jea.16.154
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发表时间：
2006-07
影响因子：
4.7
通讯作者：
Aoki K
中科院分区：
文献类型：
--
作者：
Ito Y;Kurata M;Suzuki K;Hamajima N;Hishida H;Aoki K
一些观察性流行病学研究表明，饮食和血清类胡萝卜素与降低心血管疾病死亡率有关。受试者3,061人(男性1,190人，女性1,871人)，年龄39岁至80岁，来自日本北海道居民，1988年至1995年参加过全面健康检查计划。用高效液相色谱法分别测定血清α-胡萝卜素、β-胡萝卜素和番茄红素水平。血清总胡萝卜素水平由α-胡萝卜素、β-胡萝卜素和番茄红素水平之和组成。各血清α-胡萝卜素、β-胡萝卜素、番茄红素、总胡萝卜素、甘油三酯和丙氨酸氨基转移酶(ALT)活性按对数转换。在调整了性别、年龄和其他潜在的混杂因素后，通过COX比例风险模型估计了血清α-和β-胡萝卜素、番茄红素和总胡萝卜素的风险比。在11.9年的随访期内，队列受试者中有80人(49名男性和31名女性)死于心血管疾病，40人死于心脏病，37人死于中风。高水平的血清类胡萝卜素，如α-和β-胡萝卜素，以及番茄红素，被发现与心血管疾病死亡率的低风险比显著相关。然而，并不总是观察到血清番茄红素值高与中风死亡风险之间存在显著的负相关。高水平的血清总胡萝卜素，包括α-和β-胡萝卜素和番茄红素，可能会降低日本人心血管疾病死亡的风险。
Some observational epidemiologic studies suggest that dietary and serum carotenoids are associated with reduced cardiovascular disease mortality. Three thousand and sixty-one subjects (1,190 males and 1,871 females), aged 39 to 80 years, were recruited from residents of Hokkaido, Japan who had attended comprehensive health check-up programs from 1988 through 1995. Serum levels of α-carotene, β-carotene, and lycopene were separately determined by high-performance liquid chromatography. Serum levels of total carotene consisted of the sum of α-carotene, β-carotene, and lycopene levels. Each serum level of α-carotene, β-carotene, lycopene, total carotene, triglyceride, and alanine transaminase (ALT) activity was transformed logarithmically. The hazard ratios of serum α- and β-carotenes, lycopene, and total carotene values were estimated by the Cox proportional hazard model after adjusting for sex, age, and other potential confounding factors. During the 11.9-year follow-up period, 80 deaths (49 males and 31 females) from cardiovascular disease, 40 deaths from heart disease, and 37 deaths from stroke were identified among the cohort subjects. High serum values of carotenoids such as α- and β-carotenes, and lycopene were found to be significantly associated with low hazard ratios for cardiovascular disease mortality. However, a significant inverse association between high serum lycopene value and the risk for stroke mortality was not always observed. High serum levels of total carotene, comprising α- and β-carotenes and lycopene, may reduce the risk for cardiovascular disease mortality among the Japanese population.
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影响因子：
5
作者：
KNEKT, P;REUNANEN, A;AROMAA, A
通讯作者：
AROMAA, A
DOI：
10.1024/0300-9831.72.4.237
发表时间：
2002-07-01
影响因子：
2.3
作者：
Ito, Y;Suzuki, K;Aoki, K
通讯作者：
Aoki, K
影响因子：
8
作者：
Blum, Arnon;Monir, Merei;Ben-Arzi, Sharon
通讯作者：
Ben-Arzi, Sharon
影响因子：
9.9
作者：
Adams, HP;Davis, PH;Hansen, MD
通讯作者：
Hansen, MD
影响因子：
4.8
作者：
BENDICH, A;OLSON, JA
通讯作者：
OLSON, JA