Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma.
Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma.
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DOI：
10.1016/j.cld.2020.06.002
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发表时间：
2020-11
影响因子：
5.1
通讯作者：
Chan AT
中科院分区：
文献类型：
--
作者：
Simon TG;Chan AT
Patients with chronic liver disease are at increased risk of developing hepatocellular carcinoma (HCC). The majority of patients diagnosed with HCC have limited treatment options and a poor overall prognosis, with a 5-year survival that is less than 15%. Thus, preventing the development of HCC represents the most important and impactful strategy to improve patient outcomes. However, current guidelines lack specific recommendations for the primary prevention of HCC. Emerging data suggest that lifestyle factors – including diabetes, obesity, alcohol consumption and an unhealthy diet – play an increasingly central role in the pathogenesis of HCC, and that primary prevention strategies focused on lifestyle modification could represent an important approach to the prevention of HCC. Moreover, both experimental and epidemiological studies have identified promising chemopreventive agents for the primary prevention of HCC, including statins, aspirin and anti-diabetic drugs. However, additional research is needed to define the optimal approach to lifestyle modification that can achieve maximal HCC risk reduction.
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