Effects of inhibition of prostaglandin synthesis on uterine oxytocin receptor concentration and myometrial gap junction density in parturient rats.
Effects of inhibition of prostaglandin synthesis on uterine oxytocin receptor concentration and myometrial gap junction density in parturient rats.
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抑制前列腺素合成对临产大鼠子宫催产素受体浓度和子宫肌层间隙连接密度的影响。
DOI：
10.1095/biolreprod39.5.1117
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发表时间：
1988
影响因子：
3.6
通讯作者：
Daniel,EE
中科院分区：
文献类型：
--
作者：
Chan,WY;Berezin,I;Daniel,EE
The development of oxytocin (OT) sensitivity in the parturient uterus is associated with increases in myometrial OT receptor concentration, gap junction formation, and prostaglandin (PG) production. To investigate whether PGs mediate these responses, we measured OT responsiveness, OT receptor concentrations, and gap junction formations in uteri of Day 19, 20, 21, 22, 23 pregnant and Day 2 postpartum rats. Inhibition of endogenous PG synthesis was produced by infusion of naproxen sodium delivered by an implanted osmotic pump. Naproxen treatment, but not placebo treatment, markedly attenuated in vitro uterine PGE2, PGF2α, and PGI2releases, suppressed OT responsiveness, and prolonged gestation. The increase of OT receptor concentration that normally occurred on Day 23 term pregnancy was delayed to Day 24. Co-administration of PGF2αreversed the suppressive effects of naproxen. Naproxen treatment did not significantly affect gap junction formations on Day 23 but appeared to delay both the onset and disappearance of gap junction formations. PGF2αco-administration with naproxen also had no apparent effect on gap junction development. The inhibition of OT receptor formation but not gap junction formation on Day 23 in the presence of naproxen indicates that these two events are controlled independently. Furthermore, the failure of naproxen-treated rats to deliver at term suggests that gap junction formation in the absence of an increase in OT receptors is insufficient to initiate labor. It appears that increases in both OT receptor concentrations and gap junction densities may be required for labor.
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大鼠乳腺膜中催产素-受体相互作用所需金属离子的表征。
DOI：
10.1016/s0021-9258(18)50672-4
发表时间：
1979
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
A. Pearlmutter;M. Soloff
通讯作者：
M. Soloff
通过体外收缩妊娠率子宫产生血栓素 B2、6-酮前列腺素 F1 α 和前列腺素 F2 α。
影响因子：
3.6
作者：
N. Dubin;D. Blake;R. Ghodgaonkar;P. Egner
通讯作者：
P. Egner
大鼠子宫平滑肌细胞之间的间隙连接和直接细胞间通讯。
影响因子：
--
作者：
W. Cole;R. Garfield;J. Kirkaldy
通讯作者：
J. Kirkaldy
假妊娠大鼠子宫体外前列腺素的产生以及他莫昔芬的作用，并鉴定出 6-酮基前列腺素 F1α 是主要产物
影响因子：
7.3
作者：
Linda Fenwick;R. Jones;B. Naylor;N. Poyser;N. H. Wilson
通讯作者：
N. H. Wilson
大鼠和母猪子宫中拟议的催产素受体的表征。
DOI：
10.1016/s0021-9258(19)42892-5
发表时间：
1974
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Soloff;T. Swartz
通讯作者：
T. Swartz