The effects of cannabidiol and analgesic expectancies on experimental pain reactivity in healthy adults: A balanced placebo design trial.
The effects of cannabidiol and analgesic expectancies on experimental pain reactivity in healthy adults: A balanced placebo design trial.
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DOI：
10.1037/pha0000465
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发表时间：
2022-10
影响因子：
2.3
通讯作者：
Moskal D
中科院分区：
文献类型：
--
作者：
De Vita MJ;Maisto SA;Gilmour CE;McGuire L;Tarvin E;Moskal D
尽管它经常用于缓解疼痛，但没有实验性疼痛研究测试了大麻二酚（CBD）在人类中的镇痛作用。本研究的目的是通过实验测试CBD和接受CBD对人类疼痛反应的预期的影响。使用交叉、2 × 2因子平衡安慰剂设计、给药（给予非活性物质或给予活性CBD）和口头指令集（告知非活性物质或告知活性CBD）进行实验操作。15名健康成年人每人完成了4个单独的实验阶段。参与者在每次会议上被随机分配到不同的平衡操作条件：对照（告诉不活动-给予不活动）;期望（告诉活动CBD -给予不活动）;药物（告诉不活动-给予活动CBD）;和期望+药物（告诉活动CBD -给予活动CBD）。主要结果是疼痛阈值、耐受性、强度、不愉快、条件性疼痛调制（CPM）和抵消镇痛（OA）。说明对OA有显著的主要影响，当参与者被告知他们接受CBD时，OA反应显着更大，无论药物含量如何。相对于对照组，药物、预期和预期+药物条件下的疼痛不适显著减少。药物和期望条件分别改善CPM，而期望+药物和控制条件产生最低的CPM变化分数。我们没有检测到对疼痛阈值、耐受性或强度的显著影响。我们的研究结果表明，单独的疼痛结果可能受到CBD和/或接受CBD的预期的不同影响。CBD镇痛的心理和药理学机制的未来调查是必要的。
Despite its frequent use for pain relief, no experimental pain research has tested the analgesic effects of cannabidiol (CBD) in humans. The goal of this study was to experimentally test the effects of CBD and expectancies for receiving CBD on human pain reactivity. Using a crossover, 2 × 2 factorial balanced placebo design, drug administration (given inactive substance or given active CBD) and verbal instruction sets (told inactive substance or told active CBD) were experimentally manipulated. Fifteen healthy adults each completed 4 separate experimental sessions. Participants were randomly assigned to different counterbalanced manipulation conditions at each session: control (told inactive – given inactive); expectancy (told active CBD – given inactive); drug (told inactive – given active CBD); and expectancy+drug (told active CBD – given active CBD). Primary outcomes were pain threshold, tolerance, intensity, unpleasantness, conditioned pain modulation (CPM), and offset analgesia (OA). There was a significant main effect of instructions on OA, such that the OA response was significantly larger when participants were told that they received CBD, regardless of drug content. Pain unpleasantness was significantly reduced in the drug, expectancy, and expectancy+drug conditions, relative to the control condition. The drug and expectancy conditions separately improved CPM, whereas the expectancy+drug and control conditions produced the lowest CPM change scores. We did not detect significant effects for pain threshold, tolerance, or intensity. Our results indicated that separate pain outcomes can be differentially affected by CBD and/or expectancies for receiving CBD. Future investigations of the psychological and pharmacological mechanisms underlying CBD analgesia are warranted.
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影响因子：
3.4
作者：
Castelnuovo G;Giusti EM;Manzoni GM;Saviola D;Gabrielli S;Lacerenza M;Pietrabissa G;Cattivelli R;Spatola CAM;Rossi A;Varallo G;Novelli M;Villa V;Luzzati F;Cottini A;Lai C;Volpato E;Cavalera C;Pagnini F;Tesio V;Castelli L;Tavola M;Torta R;Arreghini M;Zanini L;Brunani A;Seitanidis I;Ventura G;Capodaglio P;D'Aniello GE;Scarpina F;Brioschi A;Bigoni M;Priano L;Mauro A;Riva G;Di Lernia D;Repetto C;Regalia C;Molinari E;Notaro P;Paolucci S;Sandrini G;Simpson S;Wiederhold BK;Gaudio S;Jackson JB;Tamburin S;Benedetti F
通讯作者：
Benedetti F
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ
影响因子：
3.6
作者：
Boivie, J
通讯作者：
Boivie, J
影响因子：
4.2
作者：
Gunn, Rachel L.;Skalski, Linda;Metrik, Jane
通讯作者：
Metrik, Jane
影响因子：
4.2
作者：
Babalonis, Shanna;Haney, Margaret;Walsh, Sharon L.
通讯作者：
Walsh, Sharon L.