Cumulative community-level lead exposure and pulse pressure: the normative aging study.
Cumulative community-level lead exposure and pulse pressure: the normative aging study.
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DOI：
10.1289/ehp.10350
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Hu H
中科院分区：
文献类型：
--
作者：
Perlstein T;Weuve J;Schwartz J;Sparrow D;Wright R;Litonjua A;Nie H;Hu H
在工业化社会中，脉压随着年龄的增长而增加，这是动脉硬化的表现。铅在血管系统中积累，与血管氧化应激有关，可促进功能性和结构性血管疾病。我们测试了一个假设，即社区水平的铅暴露累积，用K-X射线荧光测量，与一组成年男性的脉压相关。在对593名未接受抗高血压药物治疗的男性进行的横断面分析中，胫骨导联与脉压呈正相关（p < 0.001）。调整年龄、种族、糖尿病、高血压家族史、教育、腰围、饮酒、吸烟史、身高、心率、空腹血糖和总胆固醇/HDL比值后，胫骨铅水平增加五分位数仍与脉压增加相关（p趋势= 0.02）。胫骨铅水平高于中位数（19.0 μg/g）的男性平均脉压比胫骨铅水平低于中位数的男性高4.2 mmHg（95%置信区间，1.9-6.5）。相反，血铅水平与脉压无关。这些数据表明，铅暴露可能有助于观察到的增加，在脉压发生在工业化社会的老龄化。铅的积累可能会导致动脉老化，也许提供机制的洞察力，观察到的低水平铅暴露与心血管死亡率的关联。
Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease. We tested the hypothesis that cumulative community-level lead exposure, measured with K-X-ray fluorescence, is associated with pulse pressure in a cohort of adult men. In a cross-sectional analysis of 593 men not treated with antihypertensive medication, tibia lead was positively associated with pulse pressure (p < 0.001). Adjusting for age, race, diabetes, family history of hypertension, education, waist circumference, alcohol intake, smoking history, height, heart rate, fasting glucose, and total cholesterol-to-HDL ratio, increasing quintiles of tibia lead remained associated with increased pulse pressure (ptrend = 0.02). Men with tibia lead above the median (19.0 μg/g) had, on average, a 4.2-mmHg (95% confidence interval, 1.9–6.5) higher pulse pressure than men with tibia lead level below the median. In contrast, blood lead level was not associated with pulse pressure. These data indicate that lead exposure may contribute to the observed increase in pulse pressure that occurs with aging in industrialized societies. Lead accumulation may contribute to arterial aging, perhaps providing mechanistic insight into the observed association of low-level lead exposure with cardiovascular mortality.
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DOI：
10.1590/s0100-879x2001001000016
发表时间：
2001-10-01
影响因子：
2.3
作者：
Malvezzi, CK;Moreira, EG;Cordellini, S
通讯作者：
Cordellini, S
影响因子：
8.3
作者：
Mitchell, GF;Parise, H;Levy, D
通讯作者：
Levy, D
影响因子：
3.2
作者：
KHALILMANESH, F;GONICK, HC;PURDY, RE
通讯作者：
PURDY, RE
影响因子：
37.8
作者：
Lakatta, EG
通讯作者：
Lakatta, EG
影响因子：
37.8
作者：
Menke, Andy;Muntner, Paul;Guallar, Eliseo
通讯作者：
Guallar, Eliseo