Self-reported and genetically predicted effects of coffee intake on rheumatoid arthritis: Epidemiological studies and Mendelian randomization analysis.
Self-reported and genetically predicted effects of coffee intake on rheumatoid arthritis: Epidemiological studies and Mendelian randomization analysis.
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DOI：
10.3389/fnut.2022.926190
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发表时间：
2022
影响因子：
5
通讯作者：
Zeng, ZhanPeng
中科院分区：
文献类型：
--
作者：
Pu, Bin;Gu, Peng;Zheng, ChuRong;Ma, LiQiong;Zheng, XiaoHui;Zeng, ZhanPeng
关键词：
关于咖啡摄入量和类风湿性关节炎（RA）风险的因果关系研究存在争议。本研究的目的是进一步探讨咖啡摄入量和类风湿关节炎风险之间的因果关系。来自NHANES 2003-2006年的4，310名参与者被纳入流行病学研究，通过加权多变量logistic回归评估咖啡摄入量与RA之间的关联。采用来自英国生物库（428，860例）咖啡摄入量和MR-Base平台（14，361例病例和43，923例对照）RA的遗传数据，采用双样本孟德尔随机化（MR）的逆方差加权（IVW）方法来估计咖啡摄入量与RA之间的因果关系。多因素Logistic回归分析显示咖啡摄入量与RA无显著相关性。与不喝咖啡组相比，<1、1-3、≥4杯/天组中RA的比值比分别为1.297、1.378和1.125（P分别为0.204、0.098和0.698）。在MR的IVW分析中，咖啡摄入量与RA无因果关系（OR = 1.47，P = 0.218）。我们的研究并不支持咖啡摄入量和类风湿关节炎风险之间的因果关系。然而，在进一步分析咖啡摄入量和RA时，有必要考虑咖啡摄入量的有效信息，包括冲泡方法，咖啡类型和数量。
Causal research concerning coffee intake and rheumatoid arthritis (RA) risk is controversial. The objective of this study was to further explore the causal relationship between coffee intake and RA risk. The 4,310 participants from NHANES 2003–2006 were included in an epidemiological study to assess the association between coffee intake and RA by weighted multivariate logistic regression. The inverse variance weighted (IVW) method of two-sample Mendelian randomization (MR), employing genetic data from UK Biobank (428,860 cases) of coffee intake and MR-Base platform (14,361 cases and 43,923 controls) of RA, was performed to estimate the causal relationship between coffee intake and RA. Weighted multivariate logistic regression suggested no significant correlation between coffee intake and RA. Compared to the no-coffee group, the odds ratio for RA in the <1, 1–3, ≥4 cups/day group were 1.297, 1.378, and 1.125 (P = 0.204, 0.098, and 0.698, respectively). In the IVW of MR analysis, there was no causal relationship between coffee intake and RA (OR = 1.47, P = 0.218). Our study did not support a causal association between coffee intake and RA risk. However, it is necessary to consider valid information on coffee intake, including brewing method, type of coffee, and quantity, in further analysis of coffee intake and RA.
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DOI：
10.1097/ede.0000000000001422
发表时间：
2022-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
George MD;Hsu JY;Hennessy S;Chen L;Xie F;Curtis JR;Baker JF
通讯作者：
Baker JF
影响因子：
9
作者：
Padyukov L
通讯作者：
Padyukov L
影响因子：
3.4
作者：
Bae, Sang-Cheol;Lee, Young Ho
通讯作者：
Lee, Young Ho
DOI：
10.3390/ijerph18157880
发表时间：
2021-07-25
影响因子：
--
作者：
Kim SG;Kang JW;Jeong SM;Song GG;Choi SJ;Jung JH
通讯作者：
Jung JH
DOI：
10.1097/rhu.0000000000000788
发表时间：
2019-04
期刊：
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
影响因子：
--
作者：
Lamichhane D;Collins C;Constantinescu F;Walitt B;Pettinger M;Parks C;Howard BV
通讯作者：
Howard BV