Exercise moderates age-related atrophy of the medial temporal lobe.
Exercise moderates age-related atrophy of the medial temporal lobe.
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DOI：
10.1016/j.neurobiolaging.2009.03.008
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发表时间：
2011-03
影响因子：
4.2
通讯作者：
Head, Denise
中科院分区：
文献类型：
--
作者：
Bugg, Julie M.;Head, Denise
大脑结构的区域性恶化是衰老的一个典型特征，但越来越多的证据表明，锻炼可能会缓解这种衰退。本研究的目的是在全球和区域水平上考察运动投入对年龄相关性脑萎缩的横断面估计的缓和影响。在52名年龄在55-79岁的健康老年人中，对过去10年的运动参与度进行了估计，并获得了基于MRI的全球(灰色和白色)和区域体积的测量。前额叶、顶叶、颞叶、枕叶、新纹状体和内侧颞区的体积估计值被获得。较高的运动投入水平与较大的上额叶体积有关。最关键的是，运动参与选择性地减缓了年龄相关的内侧颞叶萎缩。具体地说，在从事低水平锻炼的老年人中观察到了显著的与年龄相关的萎缩，但在从事高水平锻炼的老年人中则没有观察到。这一新的发现将运动的有效性扩展到可能维持老年人内侧颞叶的完整性。
Regional deterioration of brain structure is a typical feature of aging, but emerging evidence suggests that exercise may mitigate the decline. The purpose of the present investigation was to examine the moderating influence of exercise engagement on cross-sectional estimates of age-related brain atrophy at both global and regional levels. Estimates of exercise engagement over the past 10 years and MRI-based measures of global (gray and white) and regional volumes were obtained in a sample of 52 healthy older adults aged 55 – 79. Volume estimates were obtained in prefrontal, parietal, temporal, occipital, neostriatal, and medial temporal regions. Higher levels of exercise engagement were related to larger superior frontal volumes. Most critically, exercise engagement selectively moderated age-related medial temporal lobe atrophy. Specifically, significant age-related atrophy was observed for older adults who engaged in low levels of exercise, but not for those who engaged in high levels of exercise. This novel finding extends support for the efficacy of exercise to the potential maintenance of medial temporal lobe integrity in older adults.
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影响因子：
7.6
作者：
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通讯作者：
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